UBA2 and SAE1

Number of citations of the paper that reports this interaction (PubMedID 10187858)
89

Data Source:
HPRD (in vivo, in vitro)

		UBA2	SAE1
Description		ubiquitin like modifier activating enzyme 2	SUMO1 activating enzyme subunit 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	Magnesium Ion Binding Protein Binding ATP Binding Transcription Factor Binding Transferase Activity SUMO Activating Enzyme Activity SUMO Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein Heterodimerization Activity	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation	Protein Ubiquitination Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS			Lymphocyte counts ( 27863252) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) White blood cell count ( 27863252)
Interacting Genes		14 interacting genes: BRIX1 CHEK1 ETV4 NEDD8 PARK7 RAD23B SAE1 SERBP1 SUMO1 SUMO1P1 SUMO2 SUMO3 UBC UBE2I	13 interacting genes: APP ETV4 HSPA1A HSPA2 IL3RA PTK2 SUMO1 SUMO2 SUMO3 UBA2 UBE2E3 UBE2I USP39
Entrez ID		10054	10055
HPRD ID		11658	18010
Ensembl ID		ENSG00000126261	ENSG00000142230
Uniprot IDs		Q9UBT2	A0A024R0R4 Q9UBE0
PDB IDs		1Y8Q 1Y8R 2PX9 3KYC 3KYD 4W5V 5FQ2 6CWY 6CWZ	1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ
Enriched GO Terms of Interacting Partners?
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