Novel |
MVD |
mevalonate diphosphate decarboxylase |
- Cholesterol biosynthesis
- Activation of gene expression by SREBF (SREBP)
- Synthesis of Dolichyl-phosphate
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Novel |
PIEZO1 |
piezo type mechanosensitive ion channel component 1 |
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Novel |
PRDM7 |
PR/SET domain 7 |
- Generic Transcription Pathway
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Novel |
SLC7A5 |
solute carrier family 7 member 5 |
- Basigin interactions
- Amino acid transport across the plasma membrane
- Tryptophan catabolism
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Novel |
TCF25 |
transcription factor 25 |
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Novel |
TRAPPC2L |
trafficking protein particle complex subunit 2L |
- COPII-mediated vesicle transport
- RAB GEFs exchange GTP for GDP on RABs
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TF |
transferrin |
- Platelet degranulation
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- Post-translational protein phosphorylation
- Iron uptake and transport
- Transferrin endocytosis and recycling
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- Cisplatin
- Isoflurophate
- Aluminium
- Iron
- Zinc
- Manganese
- Copper
- Dichlorvos
- Zinc acetate
- Ferrous gluconate
- Ferrous succinate
- Ferrous ascorbate
- Ferrous fumarate
- Ferrous glycine sulfate
- Aluminium phosphate
- Aluminum acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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PLK1 |
polo like kinase 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Polo-like kinase mediated events
- Golgi Cisternae Pericentriolar Stack Reorganization
- Golgi Cisternae Pericentriolar Stack Reorganization
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Phosphorylation of the APC/C
- Phosphorylation of Emi1
- Condensation of Prophase Chromosomes
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Regulation of PLK1 Activity at G2/M Transition
- Activation of NIMA Kinases NEK9, NEK6, NEK7
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- Mitotic Metaphase/Anaphase Transition
- Mitotic Telophase/Cytokinesis
- Cyclin A/B1/B2 associated events during G2/M transition
- The role of GTSE1 in G2/M progression after G2 checkpoint
- AURKA Activation by TPX2
- EML4 and NUDC in mitotic spindle formation
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- 3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
- 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
- 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
- 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
- Wortmannin
- Fostamatinib
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MAPT |
microtubule associated protein tau |
- Caspase-mediated cleavage of cytoskeletal proteins
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- Lansoprazole
- Astemizole
- Paclitaxel
- Docetaxel
- Flortaucipir F-18
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- Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
- Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
- Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome
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ABCC2 |
ATP binding cassette subfamily C member 2 |
- Heme degradation
- ABC-family proteins mediated transport
- Defective ABCC2 causes DJS
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- Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
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CDC42 |
cell division cycle 42 |
- GPVI-mediated activation cascade
- EGFR downregulation
- Rho GTPase cycle
- Regulation of actin dynamics for phagocytic cup formation
- Regulation of actin dynamics for phagocytic cup formation
- CD28 dependent Vav1 pathway
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- DCC mediated attractive signaling
- Inactivation of CDC42 and RAC1
- VEGFA-VEGFR2 Pathway
- Myogenesis
- Myogenesis
- RHO GTPases activate KTN1
- RHO GTPases activate IQGAPs
- RHO GTPases activate PAKs
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate Formins
- RHO GTPases Activate Formins
- MAPK6/MAPK4 signaling
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
- G beta:gamma signalling through CDC42
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
- Factors involved in megakaryocyte development and platelet production
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- Aminophosphonic acid-guanylate ester
- Guanosine-5'-Diphosphate
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TK1 |
thymidine kinase 1 |
- G1/S-Specific Transcription
- Pyrimidine salvage
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- Dithioerythritol
- Thymidine 5'-triphosphate
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CDKN1A |
cyclin dependent kinase inhibitor 1A |
- SCF(Skp2)-mediated degradation of p27/p21
- AKT phosphorylates targets in the cytosol
- Senescence-Associated Secretory Phenotype (SASP)
- DNA Damage/Telomere Stress Induced Senescence
- Constitutive Signaling by AKT1 E17K in Cancer
- Interleukin-4 and Interleukin-13 signaling
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- Cyclin E associated events during G1/S transition
- Cyclin D associated events in G1
- p53-Dependent G1 DNA Damage Response
- Cyclin A:Cdk2-associated events at S phase entry
- Transcriptional activation of cell cycle inhibitor p21
- The role of GTSE1 in G2/M progression after G2 checkpoint
- TFAP2 (AP-2) family regulates transcription of cell cycle factors
- Transcriptional regulation by RUNX2
- RUNX3 regulates CDKN1A transcription
- Transcriptional regulation of granulopoiesis
- FOXO-mediated transcription of cell cycle genes
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
- STAT5 activation downstream of FLT3 ITD mutants
- Signaling by FLT3 fusion proteins
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DDX39B |
DExD-box helicase 39B |
- Transport of Mature mRNA derived from an Intron-Containing Transcript
- mRNA 3'-end processing
- RNA Polymerase II Transcription Termination
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LIG1 |
DNA ligase 1 |
- POLB-Dependent Long Patch Base Excision Repair
- Early Phase of HIV Life Cycle
- Processive synthesis on the C-strand of the telomere
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- PCNA-Dependent Long Patch Base Excision Repair
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Processive synthesis on the lagging strand
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- DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
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SMN1 |
survival of motor neuron 1, telomeric |
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- Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
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ANXA7 |
annexin A7 |
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ARHGEF7 |
Rho guanine nucleotide exchange factor 7 |
- EGFR downregulation
- NRAGE signals death through JNK
- Rho GTPase cycle
- Ephrin signaling
- G alpha (12/13) signalling events
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CAMSAP3 |
calmodulin regulated spectrin associated protein family member 3 |
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DUX4 |
double homeobox 4 |
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