TUBA1A - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
MAP7D3	MAP7 domain containing 3
MAPK6	mitogen-activated protein kinase 6	MAPK6/MAPK4 signaling	Acetylsalicylic acid Minocycline
MAPRE1	microtubule associated protein RP/EB family member 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
MAX	MYC associated factor X	Transcription of E2F targets under negative control by DREAM complex Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6
MX1	MX dynamin like GTPase 1	ISG15 antiviral mechanism Interferon alpha/beta signaling
NFATC1	nuclear factor of activated T cells 1	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation	Pseudoephedrine
NUDT3	nudix hydrolase 3	Synthesis of pyrophosphates in the cytosol
PLA2G7	phospholipase A2 group VII	Synthesis, secretion, and deacylation of Ghrelin	Rilapladib (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate
S100A8	S100 calcium binding protein A8	RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins	Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
S100A9	S100 calcium binding protein A9	RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins	Calcium Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
SDC3	syndecan 3	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
SIAH1	siah E3 ubiquitin protein ligase 1	Netrin-1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
SOCS6	suppressor of cytokine signaling 6	Regulation of KIT signaling Neddylation Negative regulation of FLT3
SOCS7	suppressor of cytokine signaling 7
STARD13	StAR related lipid transfer domain containing 13	Rho GTPase cycle
SYK	spleen associated tyrosine kinase	GPVI-mediated activation cascade GPVI-mediated activation cascade FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis DAP12 signaling Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Integrin signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Interleukin-2 signaling Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide Tamatinib 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic acid Fostamatinib
TAOK2	TAO kinase 2		Dexfosfoserine Fostamatinib
TBCB	tubulin folding cofactor B	Post-chaperonin tubulin folding pathway
TIMM17A	translocase of inner mitochondrial membrane 17A	Mitochondrial protein import Mitochondrial protein import
TK1	thymidine kinase 1	G1/S-Specific Transcription Pyrimidine salvage	Dithioerythritol Thymidine 5'-triphosphate

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