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FGFR4 |
fibroblast growth factor receptor 4 |
- PI3K Cascade
- PIP3 activates AKT signaling
- betaKlotho-mediated ligand binding
- FGFR4 mutant receptor activation
- FGFR4 ligand binding and activation
- Constitutive Signaling by Aberrant PI3K in Cancer
- Phospholipase C-mediated cascade; FGFR4
- FRS-mediated FGFR4 signaling
- SHC-mediated cascade:FGFR4
- PI-3K cascade:FGFR4
- Negative regulation of FGFR4 signaling
- Signaling by FGFR4 in disease
- RAF/MAP kinase cascade
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
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- Heparin
- Ponatinib
- Lenvatinib
- Erdafitinib
- Pemigatinib
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HDAC3 |
histone deacetylase 3 |
- NR1D1 (REV-ERBA) represses gene expression
- p75NTR negatively regulates cell cycle via SC1
- PPARA activates gene expression
- PPARA activates gene expression
- NOTCH1 Intracellular Domain Regulates Transcription
- Transcriptional activation of mitochondrial biogenesis
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- HDACs deacetylate histones
- Notch-HLH transcription pathway
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
- Association of TriC/CCT with target proteins during biosynthesis
- Regulation of lipid metabolism by PPARalpha
- Circadian Clock
- Circadian Clock
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- RUNX2 regulates osteoblast differentiation
- Regulation of PTEN gene transcription
- Loss of MECP2 binding ability to the NCoR/SMRT complex
- Regulation of MECP2 expression and activity
- NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
- HCMV Early Events
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- Vorinostat
- Belinostat
- Pracinostat
- Panobinostat
- Mocetinostat
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RRM2 |
ribonucleotide reductase regulatory subunit M2 |
- Interconversion of nucleotide di- and triphosphates
- G1/S-Specific Transcription
- Transcriptional Regulation by E2F6
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- Cladribine
- Imexon
- Gallium nitrate
- Motexafin gadolinium
- GTI 2040
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AGT |
angiotensinogen |
- PPARA activates gene expression
- Metabolism of Angiotensinogen to Angiotensins
- Metabolism of Angiotensinogen to Angiotensins
- Peptide ligand-binding receptors
- G alpha (q) signalling events
- G alpha (i) signalling events
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- Zinc
- Copper
- Sparsentan
- Zinc acetate
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ANXA2 |
annexin A2 |
- Smooth Muscle Contraction
- Neutrophil degranulation
- Dissolution of Fibrin Clot
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
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- Tenecteplase
- Fluocinolone acetonide
- Lanoteplase
- Artenimol
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BCR |
BCR activator of RhoGEF and GTPase |
- Signaling by cytosolic FGFR1 fusion mutants
- Rho GTPase cycle
- Signaling by FGFR1 in disease
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- Imatinib
- Dasatinib
- Bosutinib
- Ponatinib
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- Chronic myeloid leukemia (CML)
- Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
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CDK7 |
cyclin dependent kinase 7 |
- Formation of RNA Pol II elongation complex
- Formation of the Early Elongation Complex
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
- HIV Transcription Initiation
- RNA Polymerase II HIV Promoter Escape
- Transcription of the HIV genome
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- Tat-mediated elongation of the HIV-1 transcript
- NoRC negatively regulates rRNA expression
- Formation of Incision Complex in GG-NER
- RNA Polymerase II Pre-transcription Events
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- TP53 Regulates Transcription of DNA Repair Genes
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- Cyclin E associated events during G1/S transition
- Cyclin D associated events in G1
- Cyclin A/B1/B2 associated events during G2/M transition
- Cyclin A:Cdk2-associated events at S phase entry
- mRNA Capping
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Promoter Escape
- RNA Polymerase II Promoter Escape
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Transcription Termination
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Elongation
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- RNA Pol II CTD phosphorylation and interaction with CE
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
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- Phosphonothreonine
- Alvocidib
- SNS-032
- Seliciclib
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CHUK |
component of inhibitor of nuclear factor kappa B kinase complex |
- Activation of NF-kappaB in B cells
- Activation of NF-kappaB in B cells
- ER-Phagosome pathway
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- RIP-mediated NFkB activation via ZBP1
- AKT phosphorylates targets in the cytosol
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- IKBKB deficiency causes SCID
- IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
- IkBA variant leads to EDA-ID
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- Constitutive Signaling by AKT1 E17K in Cancer
- NIK-->noncanonical NF-kB signaling
- MAP3K8 (TPL2)-dependent MAPK1/3 activation
- Interleukin-1 signaling
- TRAF6 mediated NF-kB activation
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
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- Aminosalicylic acid
- Mesalazine
- Sulfasalazine
- Acetylcysteine
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DAPK3 |
death associated protein kinase 3 |
- Caspase activation via Dependence Receptors in the absence of ligand
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- 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
- 4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid
- (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile
- Fostamatinib
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EPHA2 |
EPH receptor A2 |
- EPH-Ephrin signaling
- EPH-Ephrin signaling
- EPHA-mediated growth cone collapse
- EPHA-mediated growth cone collapse
- EPH-ephrin mediated repulsion of cells
- EPH-ephrin mediated repulsion of cells
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- Dasatinib
- Phosphoaminophosphonic Acid-Adenylate Ester
- Regorafenib
- Fostamatinib
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MAPK9 |
mitogen-activated protein kinase 9 |
- Oxidative Stress Induced Senescence
- FCERI mediated MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- Activation of the AP-1 family of transcription factors
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- Minocycline
- N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide
- Fostamatinib
- Halicin
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NMT2 |
N-myristoyltransferase 2 |
- Membrane binding and targetting of GAG proteins
- Inactivation, recovery and regulation of the phototransduction cascade
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- Myristoyl-Coa
- S-(2-oxo)pentadecylcoa
- 1-(CYCLOHEXYLAMINO)-3-(6-METHYL-3,4-DIHYDRO-1H-CARBAZOL-9(2H)-YL)PROPAN-2-OL
- (Z)-3-BENZYL-5-(2-HYDROXY-3-NITROBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE
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POLA1 |
DNA polymerase alpha 1, catalytic subunit |
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Polymerase switching on the C-strand of the telomere
- Telomere C-strand synthesis initiation
- DNA replication initiation
- Activation of the pre-replicative complex
- Polymerase switching
- Removal of the Flap Intermediate
- Processive synthesis on the lagging strand
- G1/S-Specific Transcription
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- Cladribine
- Clofarabine
- Fludarabine
- Nelarabine
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PTK2 |
protein tyrosine kinase 2 |
- Apoptotic cleavage of cellular proteins
- Regulation of actin dynamics for phagocytic cup formation
- Integrin signaling
- GRB2:SOS provides linkage to MAPK signaling for Integrins
- p130Cas linkage to MAPK signaling for integrins
- NCAM signaling for neurite out-growth
- NCAM signaling for neurite out-growth
- Signal regulatory protein family interactions
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- DCC mediated attractive signaling
- DCC mediated attractive signaling
- VEGFA-VEGFR2 Pathway
- VEGFA-VEGFR2 Pathway
- RHO GTPases Activate WASPs and WAVEs
- RAF/MAP kinase cascade
- MET activates PTK2 signaling
- Extra-nuclear estrogen signaling
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
- FCGR3A-mediated phagocytosis
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- Endostatin
- 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE
- 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE
- Fostamatinib
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SSTR3 |
somatostatin receptor 3 |
- Peptide ligand-binding receptors
- G alpha (i) signalling events
- BBSome-mediated cargo-targeting to cilium
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- Pasireotide
- Somatostatin
- Lutetium Lu 177 dotatate
- Edotreotide gallium Ga-68
|
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SULT1E1 |
sulfotransferase family 1E member 1 |
- Cytosolic sulfonation of small molecules
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- Cyclizine
- Adenosine 3',5'-diphosphate
- 3'-phospho-5'-adenylyl sulfate
- 3,3',5,5'-tetrachlorobiphenyl-4,4'-diol
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TP73 |
tumor protein p73 |
- Activation of PUMA and translocation to mitochondria
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
- TP53 Regulates Transcription of Caspase Activators and Caspases
- TP53 Regulates Transcription of Death Receptors and Ligands
- Regulation of TP53 Activity through Association with Co-factors
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
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- Zinc
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
|
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ANXA3 |
annexin A3 |
|
- Fluocinolone acetonide
- Ethanolamine
- Difluocortolone
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BCL2L1 |
BCL2 like 1 |
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Interleukin-4 and Interleukin-13 signaling
- The NLRP1 inflammasome
- RAS processing
- STAT5 activation downstream of FLT3 ITD mutants
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- 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
- Isosorbide
- Gossypol
|
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CAPN1 |
calpain 1 |
- Degradation of the extracellular matrix
- Degradation of the extracellular matrix
- Neutrophil degranulation
- Formation of the cornified envelope
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
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- 4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium
- N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide
- (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
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