TP53 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
RPS6KA3	ribosomal protein S6 kinase A3	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Acetylsalicylic acid Fostamatinib	Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
RRM2	ribonucleotide reductase regulatory subunit M2	Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6	Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
RRM2B	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes	Cladribine	Mitochondrial DNA depletion syndrome (MDS)
RUNX3	RUNX family transcription factor 3	Binding of TCF/LEF:CTNNB1 to target gene promoters RUNX3 regulates CDKN1A transcription RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates WNT signaling RUNX3 regulates YAP1-mediated transcription RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF RUNX3 regulates BCL2L11 (BIM) transcription
S100A2	S100 calcium binding protein A2		Olopatadine Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
S100A4	S100 calcium binding protein A4		Trifluoperazine Copper
S100A6	S100 calcium binding protein A6		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
S100A8	S100 calcium binding protein A8	RHO GTPases Activate NADPH Oxidases Regulation of TLR by endogenous ligand Neutrophil degranulation Metal sequestration by antimicrobial proteins	Calcium Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
S100B	S100 calcium binding protein B	Nuclear signaling by ERBB4 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	Olopatadine Calcium N-Formylmethionine Arundic acid (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
SAT1	spermidine/spermine N1-acetyltransferase 1	Interconversion of polyamines	N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine	Keratosis follicularis spinulosa decalvans
SCAMP1	secretory carrier membrane protein 1	Neutrophil degranulation
SERPINB9	serpin family B member 9		Raloxifene
SETD7	SET domain containing 7, histone lysine methyltransferase	PKMTs methylate histone lysines	S-adenosyl-L-homocysteine
SFN	stratifin	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors
SHISA5	shisa family member 5	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
SIN3A	SIN3 transcription regulator family member A	SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Factors involved in megakaryocyte development and platelet production
SIN3B	SIN3 transcription regulator family member B	NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
SIRT1	sirtuin 1	Regulation of HSF1-mediated heat shock response Circadian Clock SIRT1 negatively regulates rRNA expression SIRT1 negatively regulates rRNA expression Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation	Resveratrol Selisistat Cambinol
SLC9A9	solute carrier family 9 member A9	Sodium/Proton exchangers Defective SLC9A9 causes autism 16 (AUTS16)
SMAD2	SMAD family member 2	Signaling by NODAL Signaling by NODAL Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes	Dexfosfoserine	Colorectal cancer

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