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TP73 |
tumor protein p73 |
- Activation of PUMA and translocation to mitochondria
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
- TP53 Regulates Transcription of Caspase Activators and Caspases
- TP53 Regulates Transcription of Death Receptors and Ligands
- Regulation of TP53 Activity through Association with Co-factors
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
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- Zinc
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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VEGFA |
vascular endothelial growth factor A |
- Platelet degranulation
- Regulation of gene expression by Hypoxia-inducible Factor
- Signaling by VEGF
- VEGF ligand-receptor interactions
- VEGF binds to VEGFR leading to receptor dimerization
- Interleukin-4 and Interleukin-13 signaling
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
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- Bevacizumab
- Minocycline
- Gliclazide
- Carvedilol
- Ranibizumab
- Pidolic acid
- Pegaptanib
- Vandetanib
- ABT-510
- Veglin
- Denibulin
- SNS-032
- Bevasiranib
- Dalteparin
- Aflibercept
- Chondroitin sulfate
- Foreskin keratinocyte (neonatal)
- Brolucizumab
- Faricimab
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ARNT |
aryl hydrocarbon receptor nuclear translocator |
- Regulation of gene expression by Hypoxia-inducible Factor
- PPARA activates gene expression
- Phase I - Functionalization of compounds
- Endogenous sterols
- Xenobiotics
- Aryl hydrocarbon receptor signalling
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CASP7 |
caspase 7 |
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- Apoptotic cleavage of cellular proteins
- SMAC, XIAP-regulated apoptotic response
- Caspase-mediated cleavage of cytoskeletal proteins
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- Fica
- Emricasan
- Incadronic acid
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ESR2 |
estrogen receptor 2 |
- PIP3 activates AKT signaling
- Constitutive Signaling by Aberrant PI3K in Cancer
- Nuclear Receptor transcription pathway
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- ESR-mediated signaling
- Extra-nuclear estrogen signaling
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- Diethylstilbestrol
- Conjugated estrogens
- Progesterone
- Raloxifene
- Estrone
- Tamoxifen
- Estradiol
- Trilostane
- Estramustine
- Oxybenzone
- Genistein
- Prasterone
- Benzophenone
- Phthalic Acid
- Pyrazole
- Para-Mercury-Benzenesulfonic Acid
- Naringenin
- ICI-164384
- 5-Alpha-Androstane-3-Beta,17beta-Diol
- 4-(2-{[4-{[3-(4-Chlorophenyl)Propyl]Sulfanyl}-6-(1-Piperazinyl)-1,3,5-Triazin-2-Yl]Amino}Ethyl)Phenol
- Quercetin
- Afimoxifene
- Estriol
- Estrone sulfate
- MF101
- CHF 4227
- TAS-108
- Lasofoxifene
- Arzoxifene
- Bazedoxifene
- Prinaberel
- ERB-196
- [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
- 4-(6-HYDROXY-BENZO[D]ISOXAZOL-3-YL)BENZENE-1,3-DIOL
- 2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL
- 2-(4-HYDROXY-PHENYL)BENZOFURAN-5-OL
- (3aS,4R,9bR)-2,2-difluoro-4-(4-hydroxyphenyl)-6-(methoxymethyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol
- 1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL
- 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME
- 5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE
- 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE
- 3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL
- (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- 17alpha-Estriol
- (9aS)-4-bromo-9a-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one
- Erteberel
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- Eugenol
- Octocrylene
- Enzacamene
- Equol
- 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenol
- Estradiol acetate
- Estradiol benzoate
- Estradiol cypionate
- Estradiol dienanthate
- Estradiol valerate
- Estriol tripropionate
- Fluoroestradiol F-18
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ESRRA |
estrogen related receptor alpha |
- PPARA activates gene expression
- Transcriptional activation of mitochondrial biogenesis
- Transcriptional activation of mitochondrial biogenesis
- Nuclear Receptor transcription pathway
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
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- Troglitazone
- Diethylstilbestrol
- Genistein
- Afimoxifene
- beta-Naphthoflavone
- 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE
- Flavone
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IL1B |
interleukin 1 beta |
- Interleukin-1 processing
- CLEC7A/inflammasome pathway
- Interleukin-10 signaling
- Interleukin-4 and Interleukin-13 signaling
- Interleukin-1 signaling
- Purinergic signaling in leishmaniasis infection
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- Donepezil
- Minocycline
- VP025
- Gallium nitrate
- Talmapimod
- Etiprednol dicloacetate
- VX-702
- VX-765
- Andrographolide
- Canakinumab
- Rilonacept
- Foreskin keratinocyte (neonatal)
- Binimetinib
- Gevokizumab
- Dilmapimod
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NPM1 |
nucleophosmin 1 |
- Nuclear import of Rev protein
- Nuclear import of Rev protein
- SUMOylation of transcription cofactors
- Deposition of new CENPA-containing nucleosomes at the centromere
- TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
- TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
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PSIP1 |
PC4 and SFRS1 interacting protein 1 |
- Integration of provirus
- 2-LTR circle formation
- Integration of viral DNA into host genomic DNA
- Autointegration results in viral DNA circles
- APOBEC3G mediated resistance to HIV-1 infection
- Vpr-mediated nuclear import of PICs
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RARA |
retinoic acid receptor alpha |
- Nuclear Receptor transcription pathway
- SUMOylation of intracellular receptors
- Signaling by Retinoic Acid
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
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- Adapalene
- Acitretin
- Alitretinoin
- Tretinoin
- Tazarotene
- Etretinate
- Isotretinoin
- Tamibarotene
- LGD-1550
- Trifarotene
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- Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
- Acute myeloid leukemia (AML)
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RORA |
RAR related orphan receptor A |
- RORA activates gene expression
- PPARA activates gene expression
- Nuclear Receptor transcription pathway
- Circadian Clock
- SUMOylation of intracellular receptors
- Interleukin-4 and Interleukin-13 signaling
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- Cholesterol sulfate
- Cholesterol
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AHR |
aryl hydrocarbon receptor |
- PPARA activates gene expression
- Phase I - Functionalization of compounds
- Endogenous sterols
- Xenobiotics
- Aryl hydrocarbon receptor signalling
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- Omeprazole
- Mexiletine
- Nimodipine
- Flutamide
- Atorvastatin
- Leflunomide
- Ginseng
- Indirubin-3'-monoxime
- Resveratrol
- Quercetin
- beta-Naphthoflavone
- Emodin
- 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine
- Diosmin
- Indigotindisulfonic acid
- Kynurenic Acid
- Epigallocatechin gallate
- Cantharidin
- Indirubin
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DDX5 |
DEAD-box helicase 5 |
- SUMOylation of transcription cofactors
- mRNA Splicing - Major Pathway
- Estrogen-dependent gene expression
- Replication of the SARS-CoV-1 genome
- Replication of the SARS-CoV-2 genome
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E2F2 |
E2F transcription factor 2 |
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- CDC6 association with the ORC:origin complex
- Cyclin D associated events in G1
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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EGR1 |
early growth response 1 |
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- NGF-stimulated transcription
- NGF-stimulated transcription
- Interferon alpha/beta signaling
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GATA3 |
GATA binding protein 3 |
- Ub-specific processing proteases
- Interleukin-4 and Interleukin-13 signaling
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Estrogen-dependent gene expression
- Factors involved in megakaryocyte development and platelet production
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GATA4 |
GATA binding protein 4 |
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
- Physiological factors
- Transcriptional regulation of testis differentiation
- Factors involved in megakaryocyte development and platelet production
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MEF2C |
myocyte enhancer factor 2C |
- ERK/MAPK targets
- Transcriptional activation of mitochondrial biogenesis
- Circadian Clock
- Myogenesis
- MECP2 regulates transcription factors
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- Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
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MEF2D |
myocyte enhancer factor 2D |
- Transcriptional activation of mitochondrial biogenesis
- Circadian Clock
- Myogenesis
- NGF-stimulated transcription
- NGF-stimulated transcription
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YY1 |
YY1 transcription factor |
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- UCH proteinases
- DNA Damage Recognition in GG-NER
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
- Estrogen-dependent gene expression
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