|
PRKAB2 |
protein kinase AMP-activated non-catalytic subunit beta 2 |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Macroautophagy
- AMPK inhibits chREBP transcriptional activation activity
- AMPK inhibits chREBP transcriptional activation activity
- Carnitine metabolism
- Activation of PPARGC1A (PGC-1alpha) by phosphorylation
- Energy dependent regulation of mTOR by LKB1-AMPK
- TP53 Regulates Metabolic Genes
- Regulation of TP53 Activity through Phosphorylation
- Lipophagy
- Activation of AMPK downstream of NMDARs
|
- Adenosine phosphate
- Acetylsalicylic acid
- Fostamatinib
|
|
|
CALR |
calreticulin |
- ER-Phagosome pathway
- Assembly of Viral Components at the Budding Site
- Scavenging by Class A Receptors
- Scavenging by Class A Receptors
- Scavenging by Class F Receptors
- Scavenging by Class F Receptors
- ATF6 (ATF6-alpha) activates chaperone genes
- Calnexin/calreticulin cycle
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
|
- Antihemophilic factor, human recombinant
- Tenecteplase
- Melatonin
- Lanoteplase
- Copper
- Calcium citrate
- Calcium Phosphate
- Lonoctocog alfa
- Moroctocog alfa
- Calcium phosphate dihydrate
|
|
|
RAN |
RAN, member RAS oncogene family |
- Rev-mediated nuclear export of HIV RNA
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- NEP/NS2 Interacts with the Cellular Export Machinery
- Nuclear import of Rev protein
- MicroRNA (miRNA) biogenesis
- Transcriptional regulation by small RNAs
- tRNA processing in the nucleus
- Postmitotic nuclear pore complex (NPC) reformation
- Postmitotic nuclear pore complex (NPC) reformation
|
|
|
|
BCL2L11 |
BCL2 like 11 |
- Activation of BIM and translocation to mitochondria
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- NRAGE signals death through JNK
- Signaling by BRAF and RAF fusions
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- RUNX3 regulates BCL2L11 (BIM) transcription
- FLT3 Signaling
- FOXO-mediated transcription of cell death genes
|
|
|
|
ABI2 |
abl interactor 2 |
- Regulation of actin dynamics for phagocytic cup formation
- Regulation of actin dynamics for phagocytic cup formation
- VEGFA-VEGFR2 Pathway
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate WASPs and WAVEs
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
|
|
|
|
MAP1LC3B |
microtubule associated protein 1 light chain 3 beta |
- Macroautophagy
- PINK1-PRKN Mediated Mitophagy
- TBC/RABGAPs
- Receptor Mediated Mitophagy
- Pexophagy
- Translation of Replicase and Assembly of the Replication Transcription Complex
- Translation of Replicase and Assembly of the Replication Transcription Complex
|
|
|
|
NR3C1 |
nuclear receptor subfamily 3 group C member 1 |
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Circadian Clock
- SUMOylation of intracellular receptors
- PTK6 Expression
- Regulation of RUNX2 expression and activity
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- Potential therapeutics for SARS
|
- Flunisolide
- Diflorasone
- Alclometasone
- Medrysone
- Amcinonide
- Fluorometholone
- Megestrol acetate
- Levonorgestrel
- Beclomethasone dipropionate
- Progesterone
- Spironolactone
- Betamethasone
- Desoximetasone
- Fluticasone propionate
- Fluocinolone acetonide
- Ulobetasol
- Triamcinolone
- Prednisone
- Flumethasone
- Fludrocortisone
- Norethisterone
- Hydrocortisone
- Mometasone
- Hydrocortamate
- Mifepristone
- Clocortolone
- Flurandrenolide
- Prednisolone
- Loteprednol etabonate
- Rimexolone
- Methylprednisolone
- Clobetasol propionate
- Fluocinonide
- Prednicarbate
- Fluoxymesterone
- Budesonide
- Dexamethasone
- Desonide
- Cortisone acetate
- Paramethasone
- Drospirenone
- Ciclesonide
- Hexane-1,6-Diol
- Aldosterone
- ORG-34517
- Difluprednate
- Ulipristal
- Fluticasone furoate
- Tixocortol
- Difluocortolone
- Gestrinone
- Deflazacort
- Onapristone
- Cortivazol
- Clobetasone
- Fluticasone
- Mometasone furoate
- Hydrocortisone aceponate
- Hydrocortisone acetate
- Hydrocortisone butyrate
- Hydrocortisone cypionate
- Hydrocortisone phosphate
- Hydrocortisone probutate
- Hydrocortisone valerate
- Segesterone acetate
- Prednisolone phosphate
- Dexamethasone acetate
- Betamethasone phosphate
- Prednisolone acetate
|
- 46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
|
|
SMARCA4 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
- Interleukin-7 signaling
- Formation of the beta-catenin:TCF transactivating complex
- RMTs methylate histone arginines
- Chromatin modifying enzymes
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
|
|
|
|
TAF1D |
TATA-box binding protein associated factor, RNA polymerase I subunit D |
- SIRT1 negatively regulates rRNA expression
- NoRC negatively regulates rRNA expression
- B-WICH complex positively regulates rRNA expression
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Promoter Escape
- RNA Polymerase I Transcription Termination
|
|
|
|
NCK2 |
NCK adaptor protein 2 |
- Downstream signal transduction
- Nephrin family interactions
- Ephrin signaling
- Activation of RAC1
- VEGFA-VEGFR2 Pathway
- Regulation of cortical dendrite branching
|
|
|
|
VIM |
vimentin |
- Caspase-mediated cleavage of cytoskeletal proteins
- Striated Muscle Contraction
- Interleukin-4 and Interleukin-13 signaling
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Aggrephagy
|
- Artenimol
- Phenethyl Isothiocyanate
|
|
|
GOLGA2 |
golgin A2 |
- Golgi Cisternae Pericentriolar Stack Reorganization
- Golgi Cisternae Pericentriolar Stack Reorganization
- COPII-mediated vesicle transport
- COPI-mediated anterograde transport
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
|
|
|
|
RPS6KA5 |
ribosomal protein S6 kinase A5 |
- ERK/MAPK targets
- CREB phosphorylation
- NCAM signaling for neurite out-growth
- Recycling pathway of L1
- CD209 (DC-SIGN) signaling
|
|
|
|
KLC3 |
kinesin light chain 3 |
- MHC class II antigen presentation
- RHO GTPases activate KTN1
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
|
|
|
|
MRPL53 |
mitochondrial ribosomal protein L53 |
- Mitochondrial translation initiation
- Mitochondrial translation elongation
- Mitochondrial translation elongation
- Mitochondrial translation termination
|
|
|
|
ATP5F1A |
ATP synthase F1 subunit alpha |
- Mitochondrial protein import
- Formation of ATP by chemiosmotic coupling
- Cristae formation
|
- Quercetin
- 1-ACETYL-2-CARBOXYPIPERIDINE
- AUROVERTIN B
- Piceatannol
- N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE
- Artenimol
|
|
|
GATA1 |
GATA binding protein 1 |
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Factors involved in megakaryocyte development and platelet production
|
|
- Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
- Congenital dyserythropoietic anemias (CDAs)
|
|
HNRNPM |
heterogeneous nuclear ribonucleoprotein M |
- FGFR2 alternative splicing
- mRNA Splicing - Major Pathway
- Processing of Capped Intron-Containing Pre-mRNA
|
|
|
|
KMT2C |
lysine methyltransferase 2C |
- PKMTs methylate histone lysines
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
|
|
|
|
PRMT5 |
protein arginine methyltransferase 5 |
- snRNP Assembly
- RMTs methylate histone arginines
- Regulation of TP53 Activity through Methylation
|
|
|