RB1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CCND2	cyclin D2	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)		Testicular cancer
CEBPD	CCAAT enhancer binding protein delta	Transcriptional regulation of white adipocyte differentiation Interleukin-4 and Interleukin-13 signaling HCMV Late Events
CUX1	cut like homeobox 1	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
KDM4A	lysine demethylase 4A	HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
RACK1	receptor for activated C kinase 1	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production	Copper
SPI1	Spi-1 proto-oncogene	RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis		Acute myeloid leukemia (AML)
THOC1	THO complex 1	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
TOP2A	DNA topoisomerase II alpha	Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins	Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Dactinomycin Lomefloxacin Doxorubicin Norfloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone Banoxantrone SP1049C Amonafide Elsamitrucin 13-deoxydoxorubicin RTA 744 Aldoxorubicin ZEN-012 Amrubicin Becatecarin Annamycin Declopramide Finafloxacin
TRIM27	tripartite motif containing 27	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
VDR	vitamin D receptor	Vitamin D (calciferol) metabolism Nuclear Receptor transcription pathway SUMOylation of intracellular receptors	Calcitriol Calcifediol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol Lexacalcitol Seocalcitol Cholesterol Inecalcitol Becocalcidiol CTA018 Eldecalcitol Elocalcitol Doxercalciferol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Vitamin D Curcumin Curcumin sulfate	Tuberculosis Localized autosomal recessive hypotrichosis
CDKN1C	cyclin dependent kinase inhibitor 1C	Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)		Beckwith-Wiedemann syndrome Adrenal carcinoma
ELF1	E74 like ETS transcription factor 1	RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in interleukin signaling
FANCC	FA complementation group C	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes		Fanconi anemia
FRK	fyn related Src family tyrosine kinase	Neutrophil degranulation Regulation of PTEN stability and activity	Dasatinib Regorafenib Fostamatinib Zanubrutinib
GALNT12	polypeptide N-acetylgalactosaminyltransferase 12	Defective GALNT12 causes colorectal cancer 1 (CRCS1) O-linked glycosylation of mucins
KDM5B	lysine demethylase 5B	HDMs demethylate histones TFAP2 (AP-2) family regulates transcription of cell cycle factors
LMNA	lamin A/C	XBP1(S) activates chaperone genes Signaling by BRAF and RAF fusions		Restrictive dermopathy Emery-Dreifuss muscular dystrophy Dilated cardiomyopathy (DCM) Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Mandibuloacral dysplasia Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Limb-girdle muscular dystrophy (LGMD) Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy Hutchinson-Gilford progeria syndrome
MYOD1	myogenic differentiation 1	Myogenesis Myogenesis
PELP1	proline, glutamate and leucine rich protein 1	Major pathway of rRNA processing in the nucleolus and cytosol PTK6 Expression
PRKRA	protein activator of interferon induced protein kinase EIF2AK2	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis		Primary torsion dystonia (PTD)

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