NTRK2 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
NTF4	neurotrophin 4	NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3		Primary open angle glaucoma
FRS3	fibroblast growth factor receptor substrate 3	FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3
NCK2	NCK adaptor protein 2	Downstream signal transduction Nephrin family interactions Ephrin signaling Activation of RAC1 VEGFA-VEGFR2 Pathway Regulation of cortical dendrite branching
SQSTM1	sequestosome 1	NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Interleukin-1 signaling Pexophagy		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
AP1B1	adaptor related protein complex 1 subunit beta 1	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
SHC2	SHC adaptor protein 2	Signalling to RAS Signalling to RAS VEGFA-VEGFR2 Pathway RAF/MAP kinase cascade
SHC3	SHC adaptor protein 3	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
KIDINS220	kinase D interacting substrate 220	ARMS-mediated activation ARMS-mediated activation
RASGRF1	Ras protein specific guanine nucleotide releasing factor 1	Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade
SH2B2	SH2B adaptor protein 2	Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
DOK5	docking protein 5	RET signaling
NMNAT1	nicotinamide nucleotide adenylyltransferase 1	Nicotinate metabolism	Nicotinamide Mononucleotide Deamido-Nad+
SH2B1	SH2B adaptor protein 1	Factors involved in megakaryocyte development and platelet production
SORT1	sortilin 1	Golgi Associated Vesicle Biogenesis
ERBB4	erb-b2 receptor tyrosine kinase 4		Afatinib Fostamatinib Brigatinib Zanubrutinib
GIPC1	GIPC PDZ domain containing family member 1
NDFIP1	Nedd4 family interacting protein 1

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