NF2 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
TSC1	TSC complex subunit 1	Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs		Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
BECN1	beclin 1	Macroautophagy Ub-specific processing proteases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Estradiol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
CDKN2C	cyclin dependent kinase inhibitor 2C	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
GRM1	glutamate metabotropic receptor 1	G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins	Glutamic acid (S)-alpha-methyl-4-carboxyphenylglycine
IGF1R	insulin like growth factor 1 receptor	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Extra-nuclear estrogen signaling	Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Phosphoaminophosphonic Acid-Adenylate Ester ATL1101 XL228 rhIGFBP-3 Linsitinib Teprotumumab (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE Somatrem Insulin degludec Cixutumumab Brigatinib Mecasermin rinfabate	Malignant pleural mesothelioma Synovial sarcoma
STK11	serine/threonine kinase 11	AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes		Peutz-Jeghers syndrome Pancreatic cancer
BDKRB1	bradykinin receptor B1	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Ramipril Captopril Zinc Enalaprilat Zinc acetate Zinc chloride Zinc sulfate, unspecified form
CCND2	cyclin D2	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)		Testicular cancer
EZR	ezrin	Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1
MED28	mediator complex subunit 28	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
RALGDS	ral guanine nucleotide dissociation stimulator	p38MAPK events p38MAPK events RAF/MAP kinase cascade
KDELR2	KDEL endoplasmic reticulum protein retention receptor 2	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
MAP2K3	mitogen-activated protein kinase kinase 3	Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation	Fostamatinib
MAP3K5	mitogen-activated protein kinase kinase kinase 5	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
PYGO2	pygopus family PHD finger 2	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
TARBP2	TARBP2 subunit of RISC loading complex	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
TERT	telomerase reverse transcriptase	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex	Zidovudine Grn163l Tertomotide	Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	Netrin-1 signaling
AMOTL2	angiomotin like 2	Signaling by Hippo
BYSL	bystin like	Major pathway of rRNA processing in the nucleolus and cytosol

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