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MLST8 |
MTOR associated protein, LST8 homolog |
- PIP3 activates AKT signaling
- Macroautophagy
- MTOR signalling
- mTORC1-mediated signalling
- HSF1-dependent transactivation
- Energy dependent regulation of mTOR by LKB1-AMPK
- CD28 dependent PI3K/Akt signaling
- VEGFR2 mediated vascular permeability
- TP53 Regulates Metabolic Genes
- Constitutive Signaling by AKT1 E17K in Cancer
- Regulation of TP53 Degradation
- Regulation of PTEN gene transcription
- Amino acids regulate mTORC1
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RPS6KA1 |
ribosomal protein S6 kinase A1 |
- ERK/MAPK targets
- CREB phosphorylation
- Senescence-Associated Secretory Phenotype (SASP)
- Senescence-Associated Secretory Phenotype (SASP)
- Recycling pathway of L1
- CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
- RSK activation
- RSK activation
- Gastrin-CREB signalling pathway via PKC and MAPK
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- Purvalanol A
- Fostamatinib
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SKP2 |
S-phase kinase associated protein 2 |
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- SCF(Skp2)-mediated degradation of p27/p21
- Ub-specific processing proteases
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Regulation of RUNX2 expression and activity
- Neddylation
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
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RPTOR |
regulatory associated protein of MTOR complex 1 |
- Macroautophagy
- MTOR signalling
- mTORC1-mediated signalling
- HSF1-dependent transactivation
- Energy dependent regulation of mTOR by LKB1-AMPK
- TP53 Regulates Metabolic Genes
- Regulation of PTEN gene transcription
- Amino acids regulate mTORC1
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CLIP1 |
CAP-Gly domain containing linker protein 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases activate IQGAPs
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
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FKBP1A |
FKBP prolyl isomerase 1A |
- mTORC1-mediated signalling
- Calcineurin activates NFAT
- Calcineurin activates NFAT
- TGF-beta receptor signaling activates SMADs
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGFBR1 LBD Mutants in Cancer
- Potential therapeutics for SARS
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- Pimecrolimus
- Tacrolimus
- Sirolimus
- (3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester
- {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid
- Gpi-1046
- Methyl Methylsulfinylmethyl Sulfide
- FKB-001
- Heptyl glucoside
- L-709,587
- (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine
- 4-hydroxybutan-2-one
- GPI-1485
- Myristic acid
- (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE
- Dorsomorphin
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RHEB |
Ras homolog, mTORC1 binding |
- Macroautophagy
- MTOR signalling
- mTORC1-mediated signalling
- Energy dependent regulation of mTOR by LKB1-AMPK
- TP53 Regulates Metabolic Genes
- Regulation of PTEN gene transcription
- Amino acids regulate mTORC1
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- Guanosine-5'-Triphosphate
- Guanosine-5'-Diphosphate
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RRAGB |
Ras related GTP binding B |
- Macroautophagy
- MTOR signalling
- mTORC1-mediated signalling
- Energy dependent regulation of mTOR by LKB1-AMPK
- TP53 Regulates Metabolic Genes
- Regulation of PTEN gene transcription
- Amino acids regulate mTORC1
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CFP |
complement factor properdin |
- Alternative complement activation
- Activation of C3 and C5
- Defective B3GALTL causes Peters-plus syndrome (PpS)
- O-glycosylation of TSR domain-containing proteins
- Neutrophil degranulation
- Regulation of Complement cascade
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- Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
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EIF3F |
eukaryotic translation initiation factor 3 subunit F |
- L13a-mediated translational silencing of Ceruloplasmin expression
- Translation initiation complex formation
- Formation of a pool of free 40S subunits
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
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YWHAQ |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta |
- Activation of BAD and translocation to mitochondria
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- RHO GTPases activate PKNs
- TP53 Regulates Metabolic Genes
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- Regulation of localization of FOXO transcription factors
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AKT1S1 |
AKT1 substrate 1 |
- MTOR signalling
- mTORC1-mediated signalling
- AKT phosphorylates targets in the cytosol
- HSF1-dependent transactivation
- Constitutive Signaling by AKT1 E17K in Cancer
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BCL2L1 |
BCL2 like 1 |
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Interleukin-4 and Interleukin-13 signaling
- The NLRP1 inflammasome
- RAS processing
- STAT5 activation downstream of FLT3 ITD mutants
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- 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
- Isosorbide
- Gossypol
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DCP2 |
decapping mRNA 2 |
- ATF4 activates genes in response to endoplasmic reticulum stress
- mRNA decay by 5' to 3' exoribonuclease
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
- Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
- KSRP (KHSRP) binds and destabilizes mRNA
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PRKAA1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
- Macroautophagy
- Energy dependent regulation of mTOR by LKB1-AMPK
- TP53 Regulates Metabolic Genes
- Regulation of TP53 Activity through Phosphorylation
- Activation of AMPK downstream of NMDARs
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- Adenosine phosphate
- Adenosine phosphate
- ATP
- Phenformin
- Acetylsalicylic acid
- Fostamatinib
- Fostamatinib
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RICTOR |
RPTOR independent companion of MTOR complex 2 |
- PIP3 activates AKT signaling
- CD28 dependent PI3K/Akt signaling
- VEGFR2 mediated vascular permeability
- Constitutive Signaling by AKT1 E17K in Cancer
- Regulation of TP53 Degradation
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PPP2R2A |
protein phosphatase 2 regulatory subunit Balpha |
- Initiation of Nuclear Envelope (NE) Reformation
- Cyclin D associated events in G1
- Cyclin A/B1/B2 associated events during G2/M transition
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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- 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
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PLD2 |
phospholipase D2 |
- Synthesis of PG
- Synthesis of PA
- Role of phospholipids in phagocytosis
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- Choline
- Choline salicylate
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PREX1 |
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- G alpha (12/13) signalling events
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UVRAG |
UV radiation resistance associated |
- Macroautophagy
- Translation of Replicase and Assembly of the Replication Transcription Complex
- Translation of Replicase and Assembly of the Replication Transcription Complex
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