Search Results for: LCK

148 interactions involving LCK - LCK proto-oncogene, Src family tyrosine kinase found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
ARHGAP17 Rho GTPase activating protein 17
  • Rho GTPase cycle
AXL AXL receptor tyrosine kinase
  • VEGFA-VEGFR2 Pathway
  • Fostamatinib
  • Gilteritinib
CD2 CD2 molecule
  • Cell surface interactions at the vascular wall
  • Alefacept
  • Siplizumab
CD38 CD38 molecule
  • Nicotinate metabolism
  • Daratumumab
  • Isatuximab
  • Mezagitamab
CD48 CD48 molecule
  • Cell surface interactions at the vascular wall
CD8A CD8a molecule
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
  • Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
CDKAL1 CDK5 regulatory subunit associated protein 1 like 1
  • tRNA modification in the nucleus and cytosol
  • Type II diabetes mellitus
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 1
  • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
  • Inositol 1,3,4,5-Tetrakisphosphate
DOK3 docking protein 3
  • Neutrophil degranulation
GRAP GRB2 related adaptor protein
  • Signaling by SCF-KIT
KHDRBS1 KH RNA binding domain containing, signal transduction associated 1
  • PTK6 Regulates Proteins Involved in RNA Processing
KIR2DL3 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
MAPT microtubule associated protein tau
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Lansoprazole
  • Astemizole
  • Paclitaxel
  • Docetaxel
  • Flortaucipir F-18
  • Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
  • Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
  • Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome
RIN3 Ras and Rab interactor 3
  • RAB GEFs exchange GTP for GDP on RABs
SH2D1A SH2 domain containing 1A
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
  • Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
SH2D2A SH2 domain containing 2A
  • VEGFA-VEGFR2 Pathway
SKAP2 src kinase associated phosphoprotein 2
  • Signal regulatory protein family interactions
THY1 Thy-1 cell surface antigen
  • Post-translational modification: synthesis of GPI-anchored proteins
TRIM35 tripartite motif containing 35
  • Interferon gamma signaling
TRPV4 transient receptor potential cation channel subfamily V member 4
  • TRP channels
  • Cannabidiol
  • Butamben
  • Medical Cannabis
  • Nabiximols
  • Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
  • TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dysplasia, Kozlowski type (SMDK); Metatropic dysplasia; Spondyloepiphyseal dysplasia, Maroteaux type ; Parastremmatic dysplasia
  • TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA); Scapuloperoneal spinal muscle atrophy (SPSMA); Hereditary motor and sensory neuropathy type IIC (HMSN IIC)
  • Distal hereditary motor neuropathies (dHMN)

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