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TSC22D3 |
TSC22 domain family member 3 |
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TSG101 |
tumor susceptibility 101 |
- Budding and maturation of HIV virion
- Membrane binding and targetting of GAG proteins
- Endosomal Sorting Complex Required For Transport (ESCRT)
- HCMV Late Events
- Late endosomal microautophagy
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UBB |
ubiquitin B |
- Translesion synthesis by REV1
- Recognition of DNA damage by PCNA-containing replication complex
- Translesion Synthesis by POLH
- Activation of NF-kappaB in B cells
- ISG15 antiviral mechanism
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- ER-Phagosome pathway
- Downregulation of ERBB4 signaling
- Spry regulation of FGF signaling
- Downregulation of ERBB2:ERBB3 signaling
- Budding and maturation of HIV virion
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- DDX58/IFIH1-mediated induction of interferon-alpha/beta
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Membrane binding and targetting of GAG proteins
- Assembly Of The HIV Virion
- APC-Cdc20 mediated degradation of Nek2A
- Vpu mediated degradation of CD4
- Vif-mediated degradation of APOBEC3G
- EGFR downregulation
- SCF(Skp2)-mediated degradation of p27/p21
- Degradation of beta-catenin by the destruction complex
- TCF dependent signaling in response to WNT
- Downstream TCR signaling
- NRIF signals cell death from the nucleus
- p75NTR recruits signalling complexes
- NF-kB is activated and signals survival
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- NOTCH1 Intracellular Domain Regulates Transcription
- Activated NOTCH1 Transmits Signal to the Nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Separation of Sister Chromatids
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- Oncogene Induced Senescence
- Regulation of PLK1 Activity at G2/M Transition
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Stimuli-sensing channels
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- FCERI mediated NF-kB activation
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- Regulation of innate immune responses to cytosolic DNA
- Glycogen synthesis
- Autodegradation of the E3 ubiquitin ligase COP1
- Deactivation of the beta-catenin transactivating complex
- Myoclonic epilepsy of Lafora
- ABC-family proteins mediated transport
- Circadian Clock
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Asymmetric localization of PCP proteins
- Degradation of AXIN
- Degradation of DVL
- Regulation of FZD by ubiquitination
- PINK1-PRKN Mediated Mitophagy
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- Hedgehog ligand biogenesis
- Hh mutants are degraded by ERAD
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- Degradation of GLI1 by the proteasome
- Degradation of GLI2 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- Hedgehog 'on' state
- Hedgehog 'on' state
- Negative regulation of FGFR1 signaling
- Negative regulation of FGFR2 signaling
- Negative regulation of FGFR3 signaling
- Negative regulation of FGFR4 signaling
- Translesion synthesis by POLK
- Translesion synthesis by POLI
- Termination of translesion DNA synthesis
- Regulation of RAS by GAPs
- TNFR2 non-canonical NF-kB pathway
- Negative regulation of MAPK pathway
- Regulation of necroptotic cell death
- NIK-->noncanonical NF-kB signaling
- Defective CFTR causes cystic fibrosis
- MAP3K8 (TPL2)-dependent MAPK1/3 activation
- HDR through Homologous Recombination (HRR)
- MAPK6/MAPK4 signaling
- UCH proteinases
- UCH proteinases
- Josephin domain DUBs
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Metalloprotease DUBs
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Processing of DNA double-strand break ends
- DNA Damage Recognition in GG-NER
- Formation of Incision Complex in GG-NER
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Dual Incision in GG-NER
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Fanconi Anemia Pathway
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Methylation
- Negative regulation of MET activity
- CDT1 association with the CDC6:ORC:origin complex
- Orc1 removal from chromatin
- CDK-mediated phosphorylation and removal of Cdc6
- Cyclin D associated events in G1
- G2/M Checkpoints
- Stabilization of p53
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- Ubiquitin-dependent degradation of Cyclin D
- PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
- The role of GTSE1 in G2/M progression after G2 checkpoint
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- Downregulation of ERBB2 signaling
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- InlB-mediated entry of Listeria monocytogenes into host cell
- InlB-mediated entry of Listeria monocytogenes into host cell
- InlA-mediated entry of Listeria monocytogenes into host cells
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Neddylation
- ER Quality Control Compartment (ERQC)
- Regulation of expression of SLITs and ROBOs
- Regulation of expression of SLITs and ROBOs
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- TICAM1-dependent activation of IRF3/IRF7
- TICAM1,TRAF6-dependent induction of TAK1 complex
- Interleukin-1 signaling
- Peroxisomal protein import
- Peroxisomal protein import
- Regulation of signaling by CBL
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Iron uptake and transport
- Negative regulators of DDX58/IFIH1 signaling
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- IRAK2 mediated activation of TAK1 complex
- TRAF6-mediated induction of TAK1 complex within TLR4 complex
- Negative regulation of NOTCH4 signaling
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Prevention of phagosomal-lysosomal fusion
- Modulation by Mtb of host immune system
- Alpha-protein kinase 1 signaling pathway
- Aggrephagy
- Aggrephagy
- RAS processing
- Pexophagy
- Maturation of protein E
- Maturation of protein E
- Negative regulation of FLT3
- FLT3 signaling by CBL mutants
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- Amyloid fiber formation
- Antigen processing: Ubiquitination & Proteasome degradation
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UBC |
ubiquitin C |
- Translesion synthesis by REV1
- Recognition of DNA damage by PCNA-containing replication complex
- Translesion Synthesis by POLH
- Activation of NF-kappaB in B cells
- ISG15 antiviral mechanism
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- ER-Phagosome pathway
- Downregulation of ERBB4 signaling
- Spry regulation of FGF signaling
- Downregulation of ERBB2:ERBB3 signaling
- Budding and maturation of HIV virion
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- DDX58/IFIH1-mediated induction of interferon-alpha/beta
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Membrane binding and targetting of GAG proteins
- Assembly Of The HIV Virion
- APC-Cdc20 mediated degradation of Nek2A
- Vpu mediated degradation of CD4
- Vif-mediated degradation of APOBEC3G
- EGFR downregulation
- SCF(Skp2)-mediated degradation of p27/p21
- Degradation of beta-catenin by the destruction complex
- TCF dependent signaling in response to WNT
- Downstream TCR signaling
- NRIF signals cell death from the nucleus
- p75NTR recruits signalling complexes
- NF-kB is activated and signals survival
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- NOTCH1 Intracellular Domain Regulates Transcription
- Activated NOTCH1 Transmits Signal to the Nucleus
- Activated NOTCH1 Transmits Signal to the Nucleus
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Separation of Sister Chromatids
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- Oncogene Induced Senescence
- Regulation of PLK1 Activity at G2/M Transition
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Stimuli-sensing channels
- Constitutive Signaling by NOTCH1 HD Domain Mutants
- FCERI mediated NF-kB activation
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- NOTCH2 Activation and Transmission of Signal to the Nucleus
- Regulation of innate immune responses to cytosolic DNA
- Glycogen synthesis
- Autodegradation of the E3 ubiquitin ligase COP1
- Deactivation of the beta-catenin transactivating complex
- Myoclonic epilepsy of Lafora
- ABC-family proteins mediated transport
- Circadian Clock
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Asymmetric localization of PCP proteins
- Degradation of AXIN
- Degradation of DVL
- Regulation of FZD by ubiquitination
- PINK1-PRKN Mediated Mitophagy
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- Hedgehog ligand biogenesis
- Hh mutants are degraded by ERAD
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- Degradation of GLI1 by the proteasome
- Degradation of GLI2 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- Hedgehog 'on' state
- Hedgehog 'on' state
- Negative regulation of FGFR1 signaling
- Negative regulation of FGFR2 signaling
- Negative regulation of FGFR3 signaling
- Negative regulation of FGFR4 signaling
- Translesion synthesis by POLK
- Translesion synthesis by POLI
- Termination of translesion DNA synthesis
- Regulation of RAS by GAPs
- TNFR2 non-canonical NF-kB pathway
- Negative regulation of MAPK pathway
- Regulation of necroptotic cell death
- NIK-->noncanonical NF-kB signaling
- Defective CFTR causes cystic fibrosis
- MAP3K8 (TPL2)-dependent MAPK1/3 activation
- HDR through Homologous Recombination (HRR)
- MAPK6/MAPK4 signaling
- UCH proteinases
- UCH proteinases
- Josephin domain DUBs
- Ub-specific processing proteases
- Ovarian tumor domain proteases
- Metalloprotease DUBs
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Processing of DNA double-strand break ends
- DNA Damage Recognition in GG-NER
- Formation of Incision Complex in GG-NER
- Gap-filling DNA repair synthesis and ligation in GG-NER
- Dual Incision in GG-NER
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Fanconi Anemia Pathway
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Methylation
- Negative regulation of MET activity
- CDT1 association with the CDC6:ORC:origin complex
- Orc1 removal from chromatin
- CDK-mediated phosphorylation and removal of Cdc6
- Cyclin D associated events in G1
- G2/M Checkpoints
- Stabilization of p53
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- Ubiquitin-dependent degradation of Cyclin D
- PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
- The role of GTSE1 in G2/M progression after G2 checkpoint
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- Downregulation of ERBB2 signaling
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- InlB-mediated entry of Listeria monocytogenes into host cell
- InlB-mediated entry of Listeria monocytogenes into host cell
- InlA-mediated entry of Listeria monocytogenes into host cells
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Regulation of PTEN localization
- Regulation of PTEN stability and activity
- Neddylation
- ER Quality Control Compartment (ERQC)
- Regulation of expression of SLITs and ROBOs
- Regulation of expression of SLITs and ROBOs
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- TICAM1-dependent activation of IRF3/IRF7
- TICAM1,TRAF6-dependent induction of TAK1 complex
- Interleukin-1 signaling
- Peroxisomal protein import
- Peroxisomal protein import
- Regulation of signaling by CBL
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Iron uptake and transport
- Negative regulators of DDX58/IFIH1 signaling
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- IRAK2 mediated activation of TAK1 complex
- TRAF6-mediated induction of TAK1 complex within TLR4 complex
- Negative regulation of NOTCH4 signaling
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Prevention of phagosomal-lysosomal fusion
- Modulation by Mtb of host immune system
- Alpha-protein kinase 1 signaling pathway
- Aggrephagy
- Aggrephagy
- RAS processing
- Pexophagy
- Maturation of protein E
- Maturation of protein E
- Negative regulation of FLT3
- FLT3 signaling by CBL mutants
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
- Amyloid fiber formation
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2I |
ubiquitin conjugating enzyme E2 I |
- Meiotic synapsis
- Vitamin D (calciferol) metabolism
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
- SUMOylation of DNA damage response and repair proteins
- SUMO E3 ligases SUMOylate target proteins
- SUMOylation of transcription factors
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- SUMOylation of transcription cofactors
- SUMOylation of transcription cofactors
- SUMOylation of SUMOylation proteins
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of chromatin organization proteins
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA replication proteins
- SUMOylation of DNA replication proteins
- SUMOylation of DNA methylation proteins
- SUMOylation of DNA methylation proteins
- SUMOylation of immune response proteins
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Postmitotic nuclear pore complex (NPC) reformation
- Maturation of nucleoprotein
- Maturation of nucleoprotein
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USP6 |
ubiquitin specific peptidase 6 |
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VAV1 |
vav guanine nucleotide exchange factor 1 |
- GPVI-mediated activation cascade
- GPVI-mediated activation cascade
- PIP3 activates AKT signaling
- Signaling by SCF-KIT
- NRAGE signals death through JNK
- Rho GTPase cycle
- Regulation of actin dynamics for phagocytic cup formation
- Constitutive Signaling by Aberrant PI3K in Cancer
- FCERI mediated MAPK activation
- FCERI mediated Ca+2 mobilization
- FCERI mediated Ca+2 mobilization
- CD28 dependent Vav1 pathway
- G alpha (12/13) signalling events
- VEGFA-VEGFR2 Pathway
- VEGFA-VEGFR2 Pathway
- Interleukin-3, Interleukin-5 and GM-CSF signaling
- VEGFR2 mediated vascular permeability
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- Erythropoietin activates RAS
- Erythropoietin activates RAS
- Regulation of signaling by CBL
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
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VDR |
vitamin D receptor |
- Vitamin D (calciferol) metabolism
- Nuclear Receptor transcription pathway
- SUMOylation of intracellular receptors
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- Calcitriol
- Calcifediol
- Ergocalciferol
- Cholecalciferol
- Paricalcitol
- Dihydrotachysterol
- Alfacalcidol
- Calcipotriol
- Lexacalcitol
- Seocalcitol
- Cholesterol
- Inecalcitol
- Becocalcidiol
- CTA018
- Eldecalcitol
- Elocalcitol
- Doxercalciferol
- (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol
- 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)
- Vitamin D
- Curcumin
- Curcumin sulfate
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- Tuberculosis
- Localized autosomal recessive hypotrichosis
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ZBTB7C |
zinc finger and BTB domain containing 7C |
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