HSP90AB1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
HSF1	heat shock transcription factor 1	Regulation of HSF1-mediated heat shock response HSF1 activation Attenuation phase HSF1-dependent transactivation Aggrephagy	Bimoclomol
IKBKB	inhibitor of nuclear factor kappa B kinase subunit beta	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Mesalazine Sulfasalazine Acetylsalicylic acid Auranofin Arsenic trioxide MLN0415 Acetylcysteine Ertiprotafib Fostamatinib
IKBKE	inhibitor of nuclear factor kappa B kinase subunit epsilon	SUMOylation of immune response proteins TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	Fostamatinib
ITGB1BP2	integrin subunit beta 1 binding protein 2
KEAP1	kelch like ECH associated protein 1	Ub-specific processing proteases Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Dimethyl fumarate
MAP3K14	mitogen-activated protein kinase kinase kinase 14	CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
MAP3K3	mitogen-activated protein kinase kinase kinase 3	Interleukin-1 signaling	Fostamatinib
MAPK6	mitogen-activated protein kinase 6	MAPK6/MAPK4 signaling	Acetylsalicylic acid Minocycline
MAST1	microtubule associated serine/threonine kinase 1		Fostamatinib
MKNK1	MAPK interacting serine/threonine kinase 1	Spry regulation of FGF signaling	Fostamatinib
NR2C2	nuclear receptor subfamily 2 group C member 2	Nuclear Receptor transcription pathway
NR4A1	nuclear receptor subfamily 4 group A member 1	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
POT1	protection of telomeres 1	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
PPID	peptidylprolyl isomerase D	ESR-mediated signaling
PTGES3	prostaglandin E synthase 3	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS	Acetaminophen Grn163l Copper
RHOBTB2	Rho related BTB domain containing 2	RHOBTB2 GTPase cycle
SERPINB5	serpin family B member 5		S,S-(2-Hydroxyethyl)Thiocysteine
SGTA	small glutamine rich tetratricopeptide repeat co-chaperone alpha	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
SIRPA	signal regulatory protein alpha	Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
STARD13	StAR related lipid transfer domain containing 13	Rho GTPase cycle

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