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IRF3 |
interferon regulatory factor 3 |
- ISG15 antiviral mechanism
- IRF3 mediated activation of type 1 IFN
- IRF3 mediated activation of type 1 IFN
- LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
- Regulation of innate immune responses to cytosolic DNA
- IRF3-mediated induction of type I IFN
- Interferon gamma signaling
- TICAM1-dependent activation of IRF3/IRF7
- Interferon alpha/beta signaling
- TRAF3-dependent IRF activation pathway
- TRAF6 mediated IRF7 activation
- Negative regulators of DDX58/IFIH1 signaling
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
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JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- FCERI mediated MAPK activation
- Activation of the AP-1 family of transcription factors
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- MAPK6/MAPK4 signaling
- TP53 Regulates Transcription of DNA Repair Genes
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Estrogen-dependent gene expression
- WNT5:FZD7-mediated leishmania damping
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- Adapalene
- Vinblastine
- Pseudoephedrine
- Irbesartan
- Arsenic trioxide
- LGD-1550
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PRKCD |
protein kinase C delta |
- Apoptotic cleavage of cellular proteins
- Calmodulin induced events
- Effects of PIP2 hydrolysis
- SHC1 events in ERBB2 signaling
- DAG and IP3 signaling
- Role of phospholipids in phagocytosis
- G alpha (z) signalling events
- HuR (ELAVL1) binds and stabilizes mRNA
- VEGFR2 mediated cell proliferation
- CLEC7A (Dectin-1) signaling
- RHO GTPases Activate NADPH Oxidases
- Neutrophil degranulation
- Interferon gamma signaling
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- Tamoxifen
- 13-Acetylphorbol
- Ingenol mebutate
- Fostamatinib
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HDAC6 |
histone deacetylase 6 |
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- HSF1 activation
- Notch-HLH transcription pathway
- Cilium Assembly
- Transcriptional regulation by RUNX2
- RUNX2 regulates osteoblast differentiation
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Aggrephagy
- Aggrephagy
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- Vorinostat
- Belinostat
- Pracinostat
- Romidepsin
- Panobinostat
- Bufexamac
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TBK1 |
TANK binding kinase 1 |
- IRF3 mediated activation of type 1 IFN
- IRF3 mediated activation of type 1 IFN
- Regulation of innate immune responses to cytosolic DNA
- STAT6-mediated induction of chemokines
- IRF3-mediated induction of type I IFN
- Interleukin-37 signaling
- TICAM1-dependent activation of IRF3/IRF7
- TRAF3-dependent IRF activation pathway
- TRAF6 mediated IRF7 activation
- Negative regulators of DDX58/IFIH1 signaling
- Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
- Potential therapeutics for SARS
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WASL |
WASP like actin nucleation promoting factor |
- Regulation of actin dynamics for phagocytic cup formation
- Regulation of actin dynamics for phagocytic cup formation
- NOSTRIN mediated eNOS trafficking
- Nephrin family interactions
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- DCC mediated attractive signaling
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate WASPs and WAVEs
- Clathrin-mediated endocytosis
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
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EIF2S1 |
eukaryotic translation initiation factor 2 subunit alpha |
- L13a-mediated translational silencing of Ceruloplasmin expression
- PERK regulates gene expression
- PERK regulates gene expression
- ABC-family proteins mediated transport
- Translation initiation complex formation
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Recycling of eIF2:GDP
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Response of EIF2AK1 (HRI) to heme deficiency
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PPARA |
peroxisome proliferator activated receptor alpha |
- RORA activates gene expression
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- PPARA activates gene expression
- PPARA activates gene expression
- Transcriptional activation of mitochondrial biogenesis
- Activation of gene expression by SREBF (SREBP)
- Transcriptional regulation of white adipocyte differentiation
- Nuclear Receptor transcription pathway
- Regulation of lipid metabolism by PPARalpha
- Circadian Clock
- SUMOylation of intracellular receptors
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- alpha-Linolenic acid
- Icosapent
- Troglitazone
- Valproic acid
- Indomethacin
- Rosiglitazone
- Fenoprofen
- Clofibrate
- Fenofibrate
- Ibuprofen
- Amiodarone
- Gemfibrozil
- Bezafibrate
- Prasterone
- N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
- Flufenamic acid
- Resveratrol
- Phthalic Acid
- Lauric acid
- Stearic acid
- Doconexent
- Palmitic Acid
- Oleic Acid
- Caprylic acid
- Arachidonic Acid
- Reglitazar
- Elafibranor
- Cardarine
- Muraglitazar
- Ertiprotafib
- Ragaglitazar
- Tesaglitazar
- GW-590735
- Indeglitazar
- Myristic acid
- Aleglitazar
- Clinofibrate
- Ciprofibrate
- Dexibuprofen
- Soybean oil
- Omega-3 fatty acids
- Myrrh
- Isoflavone
- Leukotriene B4
- Fenofibric acid
- Fish oil
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BIRC5 |
baculoviral IAP repeat containing 5 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- SUMOylation of DNA replication proteins
- RHO GTPases Activate Formins
- Interleukin-4 and Interleukin-13 signaling
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
- Mitotic Prometaphase
- Neddylation
- EML4 and NUDC in mitotic spindle formation
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- Reserpine
- Berberine
- LY2181308
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CFTR |
CF transmembrane conductance regulator |
- ABC-family proteins mediated transport
- RHO GTPases regulate CFTR trafficking
- Defective CFTR causes cystic fibrosis
- Ub-specific processing proteases
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- Chaperone Mediated Autophagy
- Late endosomal microautophagy
- Aggrephagy
- Aggrephagy
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- ATP
- Bumetanide
- Glyburide
- Ibuprofen
- Colforsin
- Phosphoaminophosphonic Acid-Adenylate Ester
- Dexfosfoserine
- Crofelemer
- Lonidamine
- Ivacaftor
- Dexibuprofen
- Lumacaftor
- Tezacaftor
- Elexacaftor
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- Cystic fibrosis (CF)
- Hereditary pancreatitis; Hereditary chronic pancreatitis
- Congenital bilateral absence of vas deferens
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CHEK1 |
checkpoint kinase 1 |
- Signaling by SCF-KIT
- Activation of ATR in response to replication stress
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- TP53 Regulates Transcription of DNA Repair Genes
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- Transcriptional Regulation by E2F6
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- XL844
- Enzastaurin
- CHIR-124
- N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDE
- 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE
- 2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID
- (2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL
- 2-(cyclohexylamino)benzoic acid
- 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE
- (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE
- 5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONE
- (5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL
- 1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA
- (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE
- 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE
- 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA
- 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID
- 4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOL
- (2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL
- (2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL
- N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE
- (5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC
- 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE
- 3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE
- 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL
- 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL
- REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE
- 1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine
- N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDE
- 5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
- [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone
- 2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-ol
- 6-MORPHOLIN-4-YL-9H-PURINE
- 1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE
- Fostamatinib
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HIF1A |
hypoxia inducible factor 1 subunit alpha |
- Regulation of gene expression by Hypoxia-inducible Factor
- Cellular response to hypoxia
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- NOTCH1 Intracellular Domain Regulates Transcription
- Circadian Clock
- Ub-specific processing proteases
- Interleukin-4 and Interleukin-13 signaling
- PTK6 Expression
- PTK6 promotes HIF1A stabilization
- Neddylation
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- Carvedilol
- Hydralazine
- 2-Methoxyestradiol
- ENMD-1198
- PX-478
- FG-2216
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APAF1 |
apoptotic peptidase activating factor 1 |
- Formation of apoptosome
- Activation of caspases through apoptosome-mediated cleavage
- SMAC (DIABLO) binds to IAPs
- SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
- Neutrophil degranulation
- TP53 Regulates Transcription of Caspase Activators and Caspases
- Transcriptional Regulation by E2F6
- Regulation of the apoptosome activity
- Regulation of the apoptosome activity
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CSNK2A1 |
casein kinase 2 alpha 1 |
- Synthesis of PC
- WNT mediated activation of DVL
- Condensation of Prometaphase Chromosomes
- Signal transduction by L1
- Regulation of TP53 Activity through Phosphorylation
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
- Receptor Mediated Mitophagy
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of PTEN stability and activity
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- ATP
- (5-hydroxyindolo[1,2-a]quinazolin-7-yl)acetic acid
- 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One
- Resveratrol
- 1,8-Di-Hydroxy-4-Nitro-Anthraquinone
- Benzamidine
- 5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone
- Quercetin
- Phosphoaminophosphonic Acid-Adenylate Ester
- Tetrabromo-2-Benzotriazole
- DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE
- S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE
- N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE
- Emodin
- 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE
- 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one
- N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE
- 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
- 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
- 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
- 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
- N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE
- Dichlororibofuranosylbenzimidazole
- Quinalizarin
- Ellagic acid
- Fostamatinib
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CSNK2A2 |
casein kinase 2 alpha 2 |
- Synthesis of PC
- WNT mediated activation of DVL
- Condensation of Prometaphase Chromosomes
- Signal transduction by L1
- Regulation of TP53 Activity through Phosphorylation
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
- Receptor Mediated Mitophagy
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of PTEN stability and activity
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- [1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid
- Fostamatinib
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MMP2 |
matrix metallopeptidase 2 |
- Collagen degradation
- Collagen degradation
- Degradation of the extracellular matrix
- Degradation of the extracellular matrix
- Activation of Matrix Metalloproteinases
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- EPH-ephrin mediated repulsion of cells
- Interleukin-4 and Interleukin-13 signaling
- Extra-nuclear estrogen signaling
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- Marimastat
- Captopril
- SC-74020
- Halofuginone
- AE-941
- Endostatin
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- Choriocarcinoma
- Penile cancer
- Torg-Winchester syndrome
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CDK5R1 |
cyclin dependent kinase 5 regulatory subunit 1 |
- CRMPs in Sema3A signaling
- CRMPs in Sema3A signaling
- Regulation of TP53 Activity through Phosphorylation
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- NGF-stimulated transcription
- NGF-stimulated transcription
- Activated NTRK2 signals through CDK5
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- Indirubin-3'-monoxime
- 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
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EPAS1 |
endothelial PAS domain protein 1 |
- Regulation of gene expression by Hypoxia-inducible Factor
- Cellular response to hypoxia
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Transcriptional regulation of pluripotent stem cells
- PTK6 Expression
- Neddylation
- Pexophagy
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- Congenital polycythemia; Familial erythrocytosis (ECYT)
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MS4A2 |
membrane spanning 4-domains A2 |
- Fc epsilon receptor (FCERI) signaling
- Fc epsilon receptor (FCERI) signaling
- Role of LAT2/NTAL/LAB on calcium mobilization
- Role of LAT2/NTAL/LAB on calcium mobilization
- FCERI mediated MAPK activation
- FCERI mediated Ca+2 mobilization
- FCERI mediated Ca+2 mobilization
- FCERI mediated NF-kB activation
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NOS3 |
nitric oxide synthase 3 |
- ROS and RNS production in phagocytes
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- eNOS activation
- NOSTRIN mediated eNOS trafficking
- NOSIP mediated eNOS trafficking
- Nitric oxide stimulates guanylate cyclase
- VEGFR2 mediated vascular permeability
- Extra-nuclear estrogen signaling
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- Arginine
- Citrulline
- Sapropterin
- Miconazole
- N,N-dimethylarginine
- L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide
- Canavanine
- 3-Bromo-7-Nitroindazole
- N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine
- N-[3-(aminomethyl)benzyl]acetamidine
- 1,2,4-Triazole-Carboxamidine
- L-N(omega)-nitroarginine-(4R)-amino-L-proline amide
- S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
- 7-Nitroindazole
- S-Ethylisothiourea
- 2-Aminothiazoline
- Se-Ethyl-Isoselenourea
- 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine
- N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane
- Cacodylic acid
- 7-Nitroindazole-2-Carboxamidine
- 6-Nitroindazole
- N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine
- N(G)-Iminoethylornithine
- 5,6-Cyclic-Tetrahydropteridine
- S-Ethyl-N-Phenyl-Isothiourea
- S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
- 6S-5,6,7,8-Tetrahydrobiopterin
- S-(Dimethylarsenic)Cysteine
- L-homoarginine
- S-Isopropyl-Isothiourea
- Nitroarginine
- 5-Nitroindazole
- N-(Chlorophenyl)-N'-hydroxyguanidine
- (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine
- 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE
- ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
- N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
- N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
- Levamlodipine
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