HRAS - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
TLR2	toll like receptor 2	ER-Phagosome pathway Beta defensins MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Modulation by Mtb of host immune system	Lyme disease vaccine (recombinant OspA) Adapalene S-(Dimethylarsenic)Cysteine Golotimod Tuberculin purified protein derivative
TLR6	toll like receptor 6	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand
TLR9	toll like receptor 9	PI3K Cascade Trafficking and processing of endosomal TLR Toll Like Receptor 9 (TLR9) Cascade Potential therapeutics for SARS TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome	Chloroquine Hydroxychloroquine ISS-1018 Golotimod CPG 10101
TTC1	tetratricopeptide repeat domain 1
TTC21A	tetratricopeptide repeat domain 21A
TTC28	tetratricopeptide repeat domain 28
UBE3B	ubiquitin protein ligase E3B	Antigen processing: Ubiquitination & Proteasome degradation
UBE4B	ubiquitination factor E4B
USP29	ubiquitin specific peptidase 29
USP42	ubiquitin specific peptidase 42	Ub-specific processing proteases
VAV1	vav guanine nucleotide exchange factor 1	GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 dependent Vav1 pathway G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling VEGFR2 mediated vascular permeability PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
ZBTB10	zinc finger and BTB domain containing 10
ZBTB12	zinc finger and BTB domain containing 12

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