HRAS - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
PI4K2A	phosphatidylinositol 4-kinase type 2 alpha	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane
PLA2G4B	phospholipase A2 group IVB	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA XBP1(S) activates chaperone genes
PLAAT4	phospholipase A and acyltransferase 4	Acyl chain remodelling of PE
PLCE1	phospholipase C epsilon 1	Synthesis of IP3 and IP4 in the cytosol	Nephrotic syndrome and focal segmental glomerulosclerosis
PLCH2	phospholipase C eta 2	Synthesis of IP3 and IP4 in the cytosol
PRSS50	serine protease 50
PTPRJ	protein tyrosine phosphatase receptor type J	Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity Negative regulation of FLT3
RAB5C	RAB5C, member RAS oncogene family	Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
RABAC1	Rab acceptor 1
RABGEF1	RAB guanine nucleotide exchange factor 1	TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
RALGDS	ral guanine nucleotide dissociation stimulator	p38MAPK events p38MAPK events RAF/MAP kinase cascade
RAP1B	RAP1B, member of RAS oncogene family	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants
RAP1GDS1	Rap1 GTPase-GDP dissociation stimulator 1
RAPGEF1	Rap guanine nucleotide exchange factor 1	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
RASA1	RAS p21 protein activator 1	Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
RASA2	RAS p21 protein activator 2	Regulation of RAS by GAPs
RASA4	RAS p21 protein activator 4	Regulation of RAS by GAPs
RASGRF1	Ras protein specific guanine nucleotide releasing factor 1	Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade
RASGRP1	RAS guanyl releasing protein 1	Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade
RASGRP4	RAS guanyl releasing protein 4	FCERI mediated NF-kB activation RAF/MAP kinase cascade

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