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SHMT2 |
serine hydroxymethyltransferase 2 |
- Metabolism of folate and pterines
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- Pyridoxal phosphate
- Tetrahydrofolic acid
- Glycine
- Artenimol
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SREBF1 |
sterol regulatory element binding transcription factor 1 |
- RORA activates gene expression
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
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- Doconexent
- Omega-3-acid ethyl esters
- Omega-3 fatty acids
- Fish oil
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TUBA1B |
tubulin alpha 1b |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
- Gap junction assembly
- MHC class II antigen presentation
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Recruitment of NuMA to mitotic centrosomes
- Formation of tubulin folding intermediates by CCT/TriC
- Post-chaperonin tubulin folding pathway
- Recycling pathway of L1
- Recycling pathway of L1
- Hedgehog 'off' state
- Cilium Assembly
- Intraflagellar transport
- RHO GTPases activate IQGAPs
- RHO GTPases Activate Formins
- COPI-mediated anterograde transport
- COPI-dependent Golgi-to-ER retrograde traffic
- COPI-independent Golgi-to-ER retrograde traffic
- Mitotic Prometaphase
- The role of GTSE1 in G2/M progression after G2 checkpoint
- Carboxyterminal post-translational modifications of tubulin
- Carboxyterminal post-translational modifications of tubulin
- HCMV Early Events
- Assembly and cell surface presentation of NMDA receptors
- Activation of AMPK downstream of NMDARs
- Aggrephagy
- Aggrephagy
- EML4 and NUDC in mitotic spindle formation
- Sealing of the nuclear envelope (NE) by ESCRT-III
- Kinesins
|
- Epothilone D
- Patupilone
- CYT997
- 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
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TUBA1C |
tubulin alpha 1c |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
- Gap junction assembly
- MHC class II antigen presentation
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Recruitment of NuMA to mitotic centrosomes
- Prefoldin mediated transfer of substrate to CCT/TriC
- Formation of tubulin folding intermediates by CCT/TriC
- Post-chaperonin tubulin folding pathway
- Recycling pathway of L1
- Recycling pathway of L1
- Hedgehog 'off' state
- Cilium Assembly
- Intraflagellar transport
- RHO GTPases activate IQGAPs
- RHO GTPases Activate Formins
- COPI-mediated anterograde transport
- COPI-dependent Golgi-to-ER retrograde traffic
- COPI-independent Golgi-to-ER retrograde traffic
- Mitotic Prometaphase
- The role of GTSE1 in G2/M progression after G2 checkpoint
- Carboxyterminal post-translational modifications of tubulin
- Carboxyterminal post-translational modifications of tubulin
- HCMV Early Events
- Assembly and cell surface presentation of NMDA receptors
- Activation of AMPK downstream of NMDARs
- Aggrephagy
- Aggrephagy
- EML4 and NUDC in mitotic spindle formation
- Sealing of the nuclear envelope (NE) by ESCRT-III
- Kinesins
|
- Epothilone D
- Patupilone
- CYT997
- 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
|
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CFL1 |
cofilin 1 |
- Platelet degranulation
- Regulation of actin dynamics for phagocytic cup formation
- EPHB-mediated forward signaling
- Sema3A PAK dependent Axon repulsion
- RHO GTPases Activate ROCKs
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
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- Dodecyldimethylamine N-oxide
- Copper
- Artenimol
|
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HDAC9 |
histone deacetylase 9 |
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Notch-HLH transcription pathway
|
- Valproic acid
- Belinostat
- Panobinostat
|
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HNF4A |
hepatocyte nuclear factor 4 alpha |
- Nuclear Receptor transcription pathway
|
- Lauric acid
- AVI-4557
- Myristic acid
|
- Maturity onset diabetes of the young (MODY)
|
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HSPB1 |
heat shock protein family B (small) member 1 |
- VEGFA-VEGFR2 Pathway
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- MAPK6/MAPK4 signaling
- Extra-nuclear estrogen signaling
|
- Apatorsen
- Artenimol
- Phenethyl Isothiocyanate
|
- Distal hereditary motor neuropathies (dHMN)
|
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KRT10 |
keratin 10 |
- Keratinization
- Formation of the cornified envelope
|
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- Ichthyosis with confetti; Congenital reticular ichthyosiform erythroderma; Ichthyosis variegata
- Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE)
|
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KRT8 |
keratin 8 |
- Keratinization
- Formation of the cornified envelope
|
- Tenecteplase
- Lanoteplase
- Copper
|
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PHB2 |
prohibitin 2 |
|
- Capsaicin
- Rocaglamide
- Didesmethylrocaglamide
|
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PTGES3 |
prostaglandin E synthase 3 |
- Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- HSF1 activation
- Attenuation phase
- Aryl hydrocarbon receptor signalling
- ESR-mediated signaling
- Estrogen-dependent gene expression
- Potential therapeutics for SARS
|
- Acetaminophen
- Grn163l
- Copper
|
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CSNK2B |
casein kinase 2 beta |
- Synthesis of PC
- WNT mediated activation of DVL
- Condensation of Prometaphase Chromosomes
- Signal transduction by L1
- Neutrophil degranulation
- Regulation of TP53 Activity through Phosphorylation
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
- Receptor Mediated Mitophagy
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of PTEN stability and activity
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DUT |
deoxyuridine triphosphatase |
|
- Deoxyuridine-5'-Diphosphate
- 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE
|
|
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FUBP1 |
far upstream element binding protein 1 |
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- Irofulven
- Sacituzumab govitecan
|
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GNAI1 |
G protein subunit alpha i1 |
- PLC beta mediated events
- PLC beta mediated events
- Adenylate cyclase inhibitory pathway
- Adenylate cyclase inhibitory pathway
- G-protein activation
- ADP signalling through P2Y purinoceptor 12
- Adrenaline,noradrenaline inhibits insulin secretion
- Adrenaline,noradrenaline inhibits insulin secretion
- G alpha (s) signalling events
- G alpha (i) signalling events
- G alpha (i) signalling events
- G alpha (z) signalling events
- Regulation of insulin secretion
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
- Extra-nuclear estrogen signaling
- ADORA2B mediated anti-inflammatory cytokines production
|
- Guanosine-5'-Diphosphate
- Tetrafluoroaluminate Ion
|
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GRB2 |
growth factor receptor bound protein 2 |
- Interleukin-15 signaling
- Interleukin-15 signaling
- STAT5 activation downstream of FLT3 ITD mutants
- Signaling by FLT3 ITD and TKD mutants
- Signaling by FLT3 ITD and TKD mutants
|
- Pegademase
- 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
|
|
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HDAC5 |
histone deacetylase 5 |
- NOTCH1 Intracellular Domain Regulates Transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Notch-HLH transcription pathway
- Regulation of PTEN gene transcription
|
|
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HNRNPA2B1 |
heterogeneous nuclear ribonucleoprotein A2/B1 |
- mRNA Splicing - Major Pathway
- Processing of Capped Intron-Containing Pre-mRNA
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
|
|
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KAT5 |
lysine acetyltransferase 5 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- DNA Damage/Telomere Stress Induced Senescence
- HATs acetylate histones
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Sensing of DNA Double Strand Breaks
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Estrogen-dependent gene expression
|
- Coenzyme A
- S-Acetyl-Cysteine
|
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