CDKN2A - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SEC61B	SEC61 translocon subunit beta	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
SLC4A1	solute carrier family 4 member 1 (Diego blood group)	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Bicarbonate transporters Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH) Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP) Distal renal tubular acidosis (RTA type 1)
STK11	serine/threonine kinase 11	AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes		Peutz-Jeghers syndrome Pancreatic cancer
ACLY	ATP citrate lyase	ChREBP activates metabolic gene expression Neutrophil degranulation Fatty acyl-CoA biosynthesis	Bempedoic acid
ANGPTL4	angiopoietin like 4	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes
CCND2	cyclin D2	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)		Testicular cancer
CDC7	cell division cycle 7	Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6
EXOC2	exocyst complex component 2	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
GGA3	golgi associated, gamma adaptin ear containing, ARF binding protein 3	TBC/RABGAPs MET receptor recycling Amyloid fiber formation
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Copper Artenimol
HNRNPC	heterogeneous nuclear ribonucleoprotein C	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
PEX19	peroxisomal biogenesis factor 19	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
TRIM28	tripartite motif containing 28	Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events
UBE2A	ubiquitin conjugating enzyme E2 A	Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
VAMP1	vesicle associated membrane protein 1	Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type F (botF) Toxicity of botulinum toxin type G (botG)	Botulinum Toxin Type B
ACTN4	actinin alpha 4	Platelet degranulation Nephrin family interactions		Nephrotic syndrome and focal segmental glomerulosclerosis
CTBP2	C-terminal binding protein 2	Repression of WNT target genes Signaling by TCF7L2 mutants
FRAT2	FRAT regulator of WNT signaling pathway 2	Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
GALNT12	polypeptide N-acetylgalactosaminyltransferase 12	Defective GALNT12 causes colorectal cancer 1 (CRCS1) O-linked glycosylation of mucins
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	Glycolysis Gluconeogenesis	NADH Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Xanthinol Copper Artenimol

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