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INCENP |
inner centromere protein |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- SUMOylation of DNA replication proteins
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
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RAN |
RAN, member RAS oncogene family |
- Rev-mediated nuclear export of HIV RNA
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- NEP/NS2 Interacts with the Cellular Export Machinery
- Nuclear import of Rev protein
- MicroRNA (miRNA) biogenesis
- Transcriptional regulation by small RNAs
- tRNA processing in the nucleus
- Postmitotic nuclear pore complex (NPC) reformation
- Postmitotic nuclear pore complex (NPC) reformation
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XPO1 |
exportin 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Rev-mediated nuclear export of HIV RNA
- NEP/NS2 Interacts with the Cellular Export Machinery
- Downregulation of TGF-beta receptor signaling
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Deactivation of the beta-catenin transactivating complex
- HuR (ELAVL1) binds and stabilizes mRNA
- RHO GTPases Activate Formins
- MAPK6/MAPK4 signaling
- Mitotic Prometaphase
- Cyclin A/B1/B2 associated events during G2/M transition
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
- EML4 and NUDC in mitotic spindle formation
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BIRC2 |
baculoviral IAP repeat containing 2 |
- Apoptotic cleavage of cellular proteins
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- RIPK1-mediated regulated necrosis
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- TNFR2 non-canonical NF-kB pathway
- Regulation of necroptotic cell death
- TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
- Ub-specific processing proteases
- IKK complex recruitment mediated by RIP1
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BIRC3 |
baculoviral IAP repeat containing 3 |
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- RIPK1-mediated regulated necrosis
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- TNFR2 non-canonical NF-kB pathway
- Regulation of necroptotic cell death
- TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
- Ub-specific processing proteases
- IKK complex recruitment mediated by RIP1
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BIRC6 |
baculoviral IAP repeat containing 6 |
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CCDC85B |
coiled-coil domain containing 85B |
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CDCA8 |
cell division cycle associated 8 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- SUMOylation of DNA replication proteins
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
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EVI5 |
ecotropic viral integration site 5 |
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FBXL7 |
F-box and leucine rich repeat protein 7 |
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
- Neddylation
- Antigen processing: Ubiquitination & Proteasome degradation
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H3-4 |
H3.4 histone |
- Recognition and association of DNA glycosylase with site containing an affected pyrimidine
- Cleavage of the damaged pyrimidine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Recognition and association of DNA glycosylase with site containing an affected purine
- Cleavage of the damaged purine
- Cleavage of the damaged purine
- Meiotic synapsis
- Packaging Of Telomere Ends
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- Condensation of Prophase Chromosomes
- DNA Damage/Telomere Stress Induced Senescence
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- G2/M DNA damage checkpoint
- Meiotic recombination
- Inhibition of DNA recombination at telomere
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H3C14 |
H3 clustered histone 14 |
- Interleukin-7 signaling
- Interleukin-7 signaling
- Pre-NOTCH Transcription and Translation
- Formation of the beta-catenin:TCF transactivating complex
- PRC2 methylates histones and DNA
- Condensation of Prophase Chromosomes
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- HDACs deacetylate histones
- PKMTs methylate histone lysines
- HDMs demethylate histones
- HATs acetylate histones
- HATs acetylate histones
- RMTs methylate histone arginines
- Chromatin modifying enzymes
- SIRT1 negatively regulates rRNA expression
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
- NoRC negatively regulates rRNA expression
- NoRC negatively regulates rRNA expression
- B-WICH complex positively regulates rRNA expression
- DNA methylation
- Transcriptional regulation by small RNAs
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- RNA Polymerase I Promoter Opening
- RNA Polymerase I Promoter Escape
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Estrogen-dependent gene expression
- Meiotic recombination
- HCMV Early Events
- HCMV Late Events
- Transcriptional regulation of granulopoiesis
- Amyloid fiber formation
- Factors involved in megakaryocyte development and platelet production
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RASA1 |
RAS p21 protein activator 1 |
- Downstream signal transduction
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- VEGFR2 mediated cell proliferation
- Regulation of RAS by GAPs
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
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- RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
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