ATXN1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
STAM2	signal transducing adaptor molecule 2	EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT)
SUGP2	SURP and G-patch domain containing 2
SUMO1	small ubiquitin like modifier 1	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint Regulation of IFNG signaling Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation Maturation of nucleoprotein Maturation of nucleoprotein
SUPT20H	SPT20 homolog, SAGA complex component	HATs acetylate histones
SV2A	synaptic vesicle glycoprotein 2A	Toxicity of botulinum toxin type D (botD) Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type F (botF) Toxicity of botulinum toxin type E (botE)	Levetiracetam Brivaracetam Seletracetam
SYBU	syntabulin
TBC1D5	TBC1 domain family member 5
TCEANC	transcription elongation factor A N-terminal and central domain containing
TCTA	T cell leukemia translocation altered
TDP2	tyrosyl-DNA phosphodiesterase 2	Nonhomologous End-Joining (NHEJ)
TENT5A	terminal nucleotidyltransferase 5A
TENT5B	terminal nucleotidyltransferase 5B
TMX2	thioredoxin related transmembrane protein 2
TOLLIP	toll interacting protein	Neutrophil degranulation Interleukin-1 signaling
TOMM20	translocase of outer mitochondrial membrane 20	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases
TOX4	TOX high mobility group box family member 4
TP53I11	tumor protein p53 inducible protein 11
TPRX1	tetrapeptide repeat homeobox 1
TRAF2	TNF receptor associated factor 2	Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases Dimerization of procaspase-8 TNF signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation Defective RIPK1-mediated regulated necrosis
TRIM38	tripartite motif containing 38	Interferon gamma signaling

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