OXSR1 and SLC12A6

Data Source:
HPRD (two hybrid)

		OXSR1	SLC12A6
Description		oxidative stress responsive kinase 1	solute carrier family 12 member 6
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Synapse
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Ammonium Transmembrane Transporter Activity Potassium:chloride Symporter Activity
	Biological Process	Protein Phosphorylation Response To Oxidative Stress Signal Transduction Osmosensory Signaling Pathway Positive Regulation Of T Cell Chemotaxis Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Protein Autophosphorylation Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Chemokine	Angiogenesis Ion Transport Cell Volume Homeostasis Chemical Synaptic Transmission Chloride Ion Homeostasis Potassium Ion Homeostasis Cellular Hypotonic Salinity Response Ammonium Import Across Plasma Membrane Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways			Cation-coupled Chloride cotransporters Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)
Drugs		Fostamatinib	Potassium chloride
Diseases			Agenesis of the corpus callosum with peripheral neuropathy (ACCPN)
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)	Barrett's esophagus x pack-years of smoking exposure interaction ( 29551738)
Interacting Genes		10 interacting genes: APP BMPR1B PAK1 RELL1 RELL2 SLC12A1 SLC12A2 SLC12A6 SMURF1 TGFBR1	3 interacting genes: DYSF OXSR1 STK39
Entrez ID		9943	9990
HPRD ID		06809	09220
Ensembl ID		ENSG00000172939	ENSG00000140199
Uniprot IDs		O95747	A0A024R9I5 A0A024R9K8 Q6NSI7 Q9UHW9
PDB IDs		2V3S 2VWI 3DAK	6M1Y 6M22 6Y5R 6Y5V
Enriched GO Terms of Interacting Partners?
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