CDC20 and CDC6

Data Source:
BioGRID (pull down)

		CDC20	CDC6
Description		cell division cycle 20	cell division cycle 6
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GO Annotations	Cellular Component	Spindle Pole Nucleoplasm Anaphase-promoting Complex Centrosome Spindle Cytosol Perinuclear Region Of Cytoplasm	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Intercellular Bridge Spindle Midzone Mitotic Spindle
	Molecular Function	Protein Binding Protein C-terminus Binding Anaphase-promoting Complex Binding Enzyme Binding Histone Deacetylase Binding Ubiquitin Ligase Activator Activity	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding Kinase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Mitotic Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Nervous System Development Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Protein Deubiquitination Cell Differentiation Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Synaptic Plasticity Regulation Of Meiotic Nuclear Division Regulation Of Dendrite Development Cell Division Positive Regulation Of Synapse Maturation Mitotic Spindle Assembly Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process	DNA Replication Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation Traversing Start Control Point Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cytokinesis Mitotic DNA Replication Checkpoint Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Fibroblast Proliferation Cell Division Positive Regulation Of Chromosome Segregation Cellular Response To Vasopressin Cellular Response To Angiotensin
Pathways		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of Cyclin B SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of Emi1 APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Ub-specific processing proteases Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Antigen processing: Ubiquitination & Proteasome degradation	Transcription of E2F targets under negative control by DREAM complex Activation of ATR in response to replication stress CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription
Drugs
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Asthma ( 31619474)
Interacting Genes		47 interacting genes: ANAPC1 ANAPC10 ANAPC11 ANAPC2 ANAPC4 ANAPC7 APP AURKA BUB1 BUB1B CCNA1 CCNA2 CCNB1 CCT5 CDC16 CDC27 CDC6 CDK1 CDR2 CDT1 DCPS FBXO5 FZR1 HDAC1 HDAC2 HSF1 HSF2 KIF18A MAD2L1 MAD2L1BP MAD2L2 NEK2 OTUD7B PIM1 PTTG1 RASSF1 SIRT2 SOSTDC1 SPATC1 TCP1 TGFBR1 TK1 TP63 TRIP13 UBC UBE2C UBE2S	38 interacting genes: AKAP8L ATM ATRIP B3GALNT1 CCNA2 CCNB1 CCNE1 CCNF CDC14A CDC20 CDK1 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDT1 FZR1 KAT7 MCM10 MCM2 MCM3 MCM7 MYC ORC1 ORC2 ORC3 ORC5 ORC6 PCNA PPP2R3A PPP2R3B PSKH1 RPS27A SQSTM1 TERF1 UBE2K UBR1
Entrez ID		991	990
HPRD ID		04686	04022
Ensembl ID		ENSG00000117399	ENSG00000094804
Uniprot IDs		Q12834	A0A024R1S2 Q99741
PDB IDs		4GGA 4GGC 4GGD 4N14 5G04 5KHR 5KHU 5LCW 6F0X 6Q6G 6Q6H	2CCH 2CCI 4I5L 4I5N
Enriched GO Terms of Interacting Partners?
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