RBM19 and PTPN12

Data Source:
HPRD (two hybrid)

		RBM19	PTPN12
Description		RNA binding motif protein 19	protein tyrosine phosphatase non-receptor type 12
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GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Cytoplasm Membrane Nuclear Speck	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection
	Molecular Function	RNA Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	MRNA Splicing, Via Spliceosome Multicellular Organism Development Positive Regulation Of Embryonic Development	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Cytokine Stimulus Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways			SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs			Tiludronic acid
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index ( 29615537) Bone mineral density (total hip) ( 29883787) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Chronotype ( 30696823) Daytime sleep phenotypes ( 27126917) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erosive tooth wear (severe vs non-severe) ( 29898447) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate in chronic kidney disease ( 26420894) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Metabolite levels ( 23823483) Smoking status (ever vs never smokers) ( 30643258) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 2 diabetes ( 32499647)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		2 interacting genes: PTPN12 SRPK2	57 interacting genes: AATK ABL1 ANP32B APP BAG6 BCAR1 CCDC180 CGA CSH1 CSH2 CSK EFS EGFR ERBB3 ERBB4 FANCC FGFR2 FGFR4 FLT3 FRAT2 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PPP3R2 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SFRP4 SHC1 SMAD1 SMAD5 SORBS2 STX16 STX17 TENM1 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2 ZNF510
Entrez ID		9904	5782
HPRD ID		15225	02513
Ensembl ID		ENSG00000122965	ENSG00000127947
Uniprot IDs		Q9Y4C8	B4E105 Q05209
PDB IDs		2DGW	5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?
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