SNAP91 and EPS15

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SNAP91	EPS15
Description		synaptosome associated protein 91	epidermal growth factor receptor pathway substrate 15
Image		No pdb structure
GO Annotations	Cellular Component	Clathrin-coated Pit Synaptic Vesicle Clathrin-coated Vesicle Extrinsic Component Of Presynaptic Endocytic Zone Membrane	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane Clathrin Coat Of Coated Pit Early Endosome Membrane Intracellular Membrane-bounded Organelle Postsynapse Glutamatergic Synapse
	Molecular Function	SNARE Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein Kinase Binding Clathrin Heavy Chain Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Modification-dependent Protein Binding Cadherin Binding
	Biological Process	Vesicle Budding From Membrane Protein Transport Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Clathrin Coat Assembly Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Endocytosis Vesicle Organization Endosomal Transport Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Viral Entry Into Host Cell Clathrin Coat Assembly Membrane Organization Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar disorder with mood-incongruent psychosis ( 23092984) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Electrodermal activity ( 25387706) Macular thickness ( 30535121) Refractive error ( 32231278) Schizophrenia ( 28991256 29483656 30285260)	Blood urea nitrogen levels ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) IgE grass sensitization ( 22036096) PR interval ( 30046033 32439900)
Interacting Genes		15 interacting genes: ABI2 AP2A2 AP2B1 DNAJC5 EPS15 ERBB2 ERBB3 ERBB4 GEM MIPOL1 NECAP1 OGT PLCG1 TRAF3IP1 TUBA1B	49 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 FCHO1 FCHO2 GRB2 HGS ITSN1 LAPTM5 MAPK14 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL PRKN REPS2 RNF11 SCAMP1 SGIP1 SNAP91 SPART SPOPL STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 USP8
Entrez ID		9892	2060
HPRD ID		06391	08968
Ensembl ID		ENSG00000065609	ENSG00000085832
Uniprot IDs		B7Z2N2 E9PDG8 O60641	B7Z240 P42566
PDB IDs			1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2
Enriched GO Terms of Interacting Partners?
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