AREL1 and SEPTIN4

Data Source:
BioGRID (enzymatic study)

		AREL1	SEPTIN4
Description		apoptosis resistant E3 ubiquitin protein ligase 1	septin 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Septin Complex Cell Division Site Sperm Annulus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Magnesium Ion Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response	Apoptotic Process Spermatogenesis Regulation Of Exocytosis Cell Differentiation Positive Regulation Of Protein Ubiquitination Cellular Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Cytoskeleton-dependent Cytokinesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		General factor of neuroticism ( 30867560) Mood instability ( 29187730)
Interacting Genes		10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3	9 interacting genes: AREL1 BCL2 PRKN SEPTIN5 SEPTIN8 SNCA SNCAIP SNCB XIAP
Entrez ID		9870	5414
HPRD ID		13794	04738
Ensembl ID		ENSG00000119682	ENSG00000108387
Uniprot IDs		O15033	O43236
PDB IDs		6JX5
Enriched GO Terms of Interacting Partners?
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