MAGI2 and GRID2

Data Source:
HPRD (two hybrid, in vivo)

		MAGI2	GRID2
Description		membrane associated guanylate kinase, WW and PDZ domain containing 2	glutamate ionotropic receptor delta type subunit 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Late Endosome Plasma Membrane Cell-cell Junction Bicellular Tight Junction Postsynaptic Density Dendrite Protein-containing Complex Slit Diaphragm Synapse Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Ionotropic Glutamate Receptor Complex Dendritic Spine Synapse Postsynaptic Membrane Parallel Fiber To Purkinje Cell Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Protein Binding Phosphatase Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding SMAD Binding Type II Activin Receptor Binding	Ionotropic Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Scaffold Protein Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Positive Regulation Of Receptor Internalization Planar Cell Polarity Pathway Involved In Axis Elongation Signal Transduction Nervous System Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Migration Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Activin Receptor Signaling Pathway Nerve Growth Factor Signaling Pathway Receptor Clustering Negative Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Development Cellular Response To Nerve Growth Factor Stimulus	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Glutamate Receptor Signaling Pathway Regulation Of Neuron Projection Development Cerebellar Granule Cell Differentiation Ion Transmembrane Transport Cellular Protein Localization Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synapse Assembly Excitatory Postsynaptic Potential Prepulse Inhibition Regulation Of Postsynaptic Density Assembly Positive Regulation Of Long-term Synaptic Depression Excitatory Synapse Assembly
Pathways		Nephrin family interactions
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Airway wall thickness ( 25517131) Bitter beverage consumption ( 31046077) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Bronchopulmonary dysplasia ( 23897914) Chronotype ( 30696823) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) General risk tolerance (MTAG) ( 30643258) Hippocampal atrophy ( 19668339) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lead levels in blood ( 25820613) Mammographic density (dense area) ( 25342443) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Response to anti-depressant treatment in major depressive disorder ( 22041458) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125) Schizophrenia ( 28991256 30285260) Serum folate levels ( 29953918) Visceral fat ( 30942860)	Coffee consumption ( 31046077) Intelligence (MTAG) ( 29326435) Manganese levels ( 26025379) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		24 interacting genes: ACVR2A ADGRB1 ADRB1 ARRDC3 ATN1 CRHR1 CTNNB1 CTNND2 DLGAP1 DLGAP2 DLGAP3 DLL1 DSCAML1 GRID2 MORN4 PDZD11 PLEKHF2 PLXNB3 PTEN RAPGEF2 RPS6KA1 SMAD3 SNRPB TGFA	10 interacting genes: AP4M1 DLG2 EML1 GOPC GRIA1 GRID2IP GRIK2 GRIK5 MAGI2 PTPN4
Entrez ID		9863	2895
HPRD ID		16212	06781
Ensembl ID		ENSG00000187391	ENSG00000152208
Uniprot IDs		B7Z4H4 Q86UL8	O43424
PDB IDs		1UEP 1UEQ 1UEW 1UJV 1WFV	5KC8 5KCA
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?