MELK and PPP1R8

Data Source:
HPRD (in vitro)

		MELK	PPP1R8
Description		maternal embryonic leucine zipper kinase	protein phosphatase 1 regulatory subunit 8
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell Cortex Membrane	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck
	Molecular Function	Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	DNA Binding RNA Binding MRNA Binding Endonuclease Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Ribonuclease E Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Peptidyl-tyrosine Phosphorylation Hemopoiesis Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation	MRNA Processing RNA Catabolic Process Cell Population Proliferation RNA Splicing Negative Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Protein Dephosphorylation RNA Phosphodiester Bond Hydrolysis
Pathways
Drugs		Fostamatinib
Diseases
GWAS
Interacting Genes		11 interacting genes: CDC25B CDC5L EIF2S1 EZH2 H1-5 LMNB1 MAPT MBP PPP1R8 SF3B1 ZNF622	27 interacting genes: APP APPBP2 CDC5L CREBBP CRMP1 CSNK2A1 CSNK2A2 CTNNBL1 EED ERG28 FBXO25 GBP2 HDAC2 HMGA1 LRRK2 LYN MELK PPIL1 PPP1CA PPP1CC PRKACA RBM48 RTN4IP1 SETDB1 SF3B1 STC2 WDR77
Entrez ID		9833	5511
HPRD ID		06119	04028
Ensembl ID		ENSG00000165304	ENSG00000117751
Uniprot IDs		B7Z1G6 Q14680	Q12972 Q6ICT4
PDB IDs		4BKY 4BKZ 4BL1 4D2P 4D2T 4D2V 4D2W 4IXP 4UMP 4UMQ 4UMR 4UMT 4UMU 5IH8 5IH9 5IHA 5IHC 5K00 5M5A 5MAF 5MAG 5MAH 5MAI 5TVT 5TWL 5TWU 5TWY 5TWZ 5TX3 6GVX 6VXR	3V4Y
Enriched GO Terms of Interacting Partners?
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