JAKMIP2 and CLASP1

Data Source:
BioGRID (two hybrid)

		JAKMIP2	CLASP1
Description		janus kinase and microtubule interacting protein 2	cytoplasmic linker associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Microtubule Cytoskeleton	Kinetochore Condensed Chromosome Kinetochore Golgi Apparatus Centrosome Microtubule Organizing Center Kinetochore Microtubule Cytosol Spindle Microtubule Cytoplasmic Microtubule Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Centrosomal Corona Microtubule Plus-end Basal Cortex Mitotic Spindle
	Molecular Function	Protein Binding Microtubule Binding Kinase Binding	Dystroglycan Binding Protein Binding Microtubule Binding Kinetochore Binding Microtubule Plus-end Binding
	Biological Process		G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Microtubule Bundle Formation Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Regulation Of G2/M Transition Of Mitotic Cell Cycle Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Astral Microtubule Organization Microtubule Organizing Center Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Microtubule Anchoring Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Establishment Of Spindle Orientation Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Extracellular Matrix Disassembly Establishment Of Epithelial Cell Polarity Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Role of ABL in ROBO-SLIT signaling Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Body mass index (change over time) in chronic obstructive pulmonary disease ( 28044437) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Chloride levels ( 29403010) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Potassium levels ( 29403010) Triglyceride levels ( 32154731)
Interacting Genes		19 interacting genes: CCDC136 CCDC88B CLASP1 CLIP4 EFHC2 ELOA HGS HOMEZ KIF9 LINC00839 MRPL11 NAB2 NTAQ1 PIN1 PRPF31 SMARCE1 TRIM29 VPS52 ZNF263	11 interacting genes: CKAP5 JAKMIP2 MAP4 MAPRE1 MAPRE3 MARK3 MTNR1A MTNR1B SRPK2 SYBU YWHAG
Entrez ID		9832	23332
HPRD ID		11090	09322
Ensembl ID		ENSG00000176049	ENSG00000074054
Uniprot IDs		Q96AA8	Q7Z460
PDB IDs			4K92 6MQ5 6MQ7
Enriched GO Terms of Interacting Partners?
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