DNAJC6 and AP2A2

Data Source:
HPRD (in vitro)

		DNAJC6	AP2A2
Description		DnaJ heat shock protein family (Hsp40) member C6	adaptor related protein complex 2 subunit alpha 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Postsynaptic Density Vesicle Intracellular Membrane-bounded Organelle Presynapse	Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity SH3 Domain Binding Clathrin Binding	Molecular_function Protein Binding Lipid Binding Protein Kinase Binding Clathrin Adaptor Activity Disordered Domain Specific Binding Cargo Adaptor Activity
	Biological Process	Synaptic Vesicle Uncoating Peptidyl-tyrosine Dephosphorylation Membrane Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis	Intracellular Protein Transport Receptor-mediated Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Low-density Lipoprotein Particle Receptor Catabolic Process Low-density Lipoprotein Particle Clearance Neutrophil Degranulation Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Clathrin-dependent Endocytosis
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Anticoagulant levels ( 22216198) Idiopathic osteonecrosis of the femoral head ( 28000841)	Adult asthma ( 27611488) Alzheimer's disease ( 30636644) Alzheimer's disease (late onset) ( 24162737) Asthma ( 31959851) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)
Interacting Genes		3 interacting genes: AP2A2 BAG2 CLTC	18 interacting genes: AAGAB AMPH AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EPN1 EPS15 HTT NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC
Entrez ID		9829	161
HPRD ID		16326	06256
Ensembl ID		ENSG00000116675	ENSG00000183020
Uniprot IDs		O75061	O94973
PDB IDs
Enriched GO Terms of Interacting Partners?
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