IST1 and CAPN7

Data Source:
BioGRID (two hybrid)

		IST1	CAPN7
Description		IST1 factor associated with ESCRT-III	calpain 7
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GO Annotations	Cellular Component	Chromatin Extracellular Region Nuclear Envelope Endoplasmic Reticulum-Golgi Intermediate Compartment Centrosome Cytosol Midbody Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Flemming Body	Nucleus Centrosome Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Protein Domain Specific Binding Protein-containing Complex Binding Cadherin Binding MIT Domain Binding	Endopeptidase Activity Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding MIT Domain Binding
	Biological Process	Protein Localization Abscission Protein Transport Viral Release From Host Cell Multivesicular Body Assembly Neutrophil Degranulation Establishment Of Protein Localization Positive Regulation Of Proteolysis Viral Capsid Secondary Envelopment Positive Regulation Of Collateral Sprouting Cell Division Cytoskeleton-dependent Cytokinesis ESCRT III Complex Disassembly	Positive Regulation Of Epithelial Cell Migration Self Proteolysis
Pathways		Neutrophil degranulation Sealing of the nuclear envelope (NE) by ESCRT-III	Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 28240269) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: APEH ATXN1 BAG4 CAPN7 CHMP1A SPAST TOX3 UBQLN1 UBQLN2	19 interacting genes: ARNT2 AXIN2 CEP63 CTBP2 GOLGA2 IFT88 IST1 MAD1L1 MAGED1 MDM4 PPP1R13B PRPSAP1 TNFAIP1 TRIM27 UBL7 VHL ZBTB9 ZFYVE19 ZNF655
Entrez ID		9798	23473
HPRD ID		13784	05908
Ensembl ID		ENSG00000182149	ENSG00000131375
Uniprot IDs		B4DXC9 P53990	Q7Z479 Q9Y6W3
PDB IDs		3FRR 3FRS 3JC1 4U7E 4U7I 4U7Y 4WZX 6E8G 6TZ4 6TZ5 6TZA	2QFE
Enriched GO Terms of Interacting Partners?
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