DHX38 and E2F4

Data Source:
BioGRID (biochemical)

		DHX38	E2F4
Description		DEAH-box helicase 38	E2F transcription factor 4
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GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome	Chromatin Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Epithelial Cell Development Regulation Of Transcription By RNA Polymerase II Cell Volume Homeostasis DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Blood Circulation Animal Organ Morphogenesis Regulation Of Cell Population Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 28240269 23696881) Cholesterol, total ( 25961943 20686565) Coronary artery disease ( 29212778) Depression ( 29700475) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 22916037) Red blood cell count ( 32888494) Serum metabolite levels (CMS) ( 31636271) Urate levels ( 31578528)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		8 interacting genes: CDC40 CSNK2A1 MFAP1 PPP4C SNRNP200 TERF2IP U2AF1 WBP4	31 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB KAT5 LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 PIN1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1
Entrez ID		9785	1874
HPRD ID		05720	02806
Ensembl ID		ENSG00000140829	ENSG00000205250
Uniprot IDs		Q92620	Q16254
PDB IDs		5YZG 6ZYM 7A5P	1CF7 5TUU
Enriched GO Terms of Interacting Partners?
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