E2F4 and SPIB

Data Source:
BioGRID (two hybrid)

		E2F4	SPIB
Description		E2F transcription factor 4	Spi-B transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Epithelial Cell Development Regulation Of Transcription By RNA Polymerase II Cell Volume Homeostasis DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Blood Circulation Animal Organ Morphogenesis Regulation Of Cell Population Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Centriole Assembly Multi-ciliated Epithelial Cell Differentiation	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Primary biliary cholangitis ( 21399635 20639880 26394269) Systolic blood pressure ( 30224653)
Interacting Genes		31 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB KAT5 LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 PIN1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1	19 interacting genes: CEBPB CREBBP CSNK2A1 CSNK2A2 E2F1 E2F2 E2F3 E2F4 EP300 GATA1 IRF4 JUN MAPK3 MAPK8 RB1 SPI1 SSB TBP TMEM37
Entrez ID		1874	6689
HPRD ID		02806	06007
Ensembl ID		ENSG00000205250	ENSG00000269404
Uniprot IDs		Q16254	A0A024R4I5 Q01892
PDB IDs		1CF7 5TUU
Enriched GO Terms of Interacting Partners?
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