HDAC4 and GOLGA2

Data Source:
BioGRID (two hybrid)

		HDAC4	GOLGA2
Description		histone deacetylase 4	golgin A2
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Transcription Repressor Complex Z Disc Neuromuscular Junction A Band Actomyosin	Golgi Cis Cisterna Golgi Membrane Spindle Pole Golgi Apparatus Cis-Golgi Network Microtubule COPII-coated ER To Golgi Transport Vesicle Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Mitotic Spindle
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Protein Kinase Binding Potassium Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Repressing Transcription Factor Binding Promoter-specific Chromatin Binding	Protein Binding Microtubule Binding Protein Kinase Binding Syntaxin Binding Identical Protein Binding Cadherin Binding Importin-alpha Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Development Chromatin Remodeling Protein Deacetylation Inflammatory Response Nervous System Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Myotube Differentiation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Denervation Involved In Regulation Of Muscle Adaptation Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Smooth Muscle Cell Migration Histone Deacetylation Protein Sumoylation B Cell Differentiation Positive Regulation Of Protein Sumoylation Peptidyl-lysine Deacetylation Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Drug Regulation Of Protein Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of DNA-binding Transcription Factor Activity Response To Interleukin-1 Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Mechanical Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Parathyroid Hormone Stimulus Positive Regulation Of Male Mating Behavior Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Reactive Oxygen Species Biosynthetic Process	Protein Glycosylation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule Nucleation Golgi Organization Centrosome Cycle Asymmetric Cell Division Negative Regulation Of Autophagy Protein Transport Negative Regulation Of Protein Binding COPII Vesicle Coating Spindle Assembly Protein Homotetramerization Positive Regulation Of Protein Glycosylation Golgi Ribbon Formation Golgi Disassembly Spindle Assembly Involved In Meiosis Mitotic Spindle Assembly Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins RUNX2 regulates chondrocyte maturation RUNX3 regulates p14-ARF	Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Zinc Belinostat Romidepsin Panobinostat N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide 2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blond vs. brown/black hair color ( 30531825) Body size at age 10 ( 32376654) Chronotype ( 30696823) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Diastolic blood pressure ( 30224653 30487518) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Heel bone mineral density ( 30598549) Intra-individual response time variability (selective attention) ( 30287865) Male-pattern baldness ( 22693459) Mean arterial pressure ( 29403010 30487518) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure ( 30487518)	Adult body size ( 32376654) Body mass index ( 26426971)
Interacting Genes		123 interacting genes: ACTA1 ANKRA2 ANKRD11 APP AR ASB15 ATF3 ATRX BCL6 BCOR BEGAIN BICD2 BLZF1 BORCS8-MEF2B BRMS1 CACNA1C CADPS CALCOCO2 CAMK4 CBX5 CCDC125 CCDC136 CCNDBP1 CDKN1A CDPF1 CDR2 CDR2L CEBPD CEP70 CIITA CSRP3 CTBP1 DYDC1 EFEMP2 EFHC2 ESR1 FCHSD2 FSD2 GATA1 GCM1 GOLGA2 GOLGA6L9 GRIPAP1 GSK3B HAP1 HDAC3 HDAC7 HDAC9 HNF4A HOOK2 HSF2BP IFRD1 IKZF2 INCA1 JDP2 KRT27 KRT31 KRT33B KRT34 KRT35 KRT38 KRT40 LCOR LDOC1 LZTR1 MAP1S MAPK1 MAPK3 MECOM MEF2A MEF2B MEF2C MEF2D MEGF10 MID2 MIF4GD MTUS2 NACC1 NCOR2 NFKB2 NFKBID NFKBIE NPPB NR1H2 NR2C1 NR2C2 PICK1 PNMA1 PPARD PPARG PTPA RANBP2 RARA RBBP4 REV3L RFXANK RINT1 RUNX2 RUNX3 RUVBL2 RXRA SMAD3 SRF SS18L1 SSX2IP SUMO1 SUMO2 SYK TFIP11 TLE5 TNFRSF14 TRIB3 TRIM27 TSGA10 UBE2I VPS52 YWHAE YWHAG YWHAQ YWHAZ ZBTB16 ZMYND12 ZNF354A	461 interacting genes: ABHD17A ABLIM1 ADAP1 AFF4 ALKBH2 ALKBH3 AMOTL2 ANKHD1 ANKRD11 ANKRD36 ANKRD36BP1 ANKS1A APC AQP1 ARFIP2 ARHGAP45 ARHGEF6 ARID5A ARL16 ARL4A ARNT2 ARPC3 ATP5PO ATP6V1C2 ATP6V1D ATP6V1G1 ATXN7 AXIN1 BAHD1 BARD1 BAZ2B BCAS2 BCL6 BCL6B BMS1P1 BYSL C12orf50 C19orf44 C1orf109 C1orf35 C2CD6 CAB39 CAPN7 CBX8 CBY2 CCAR1 CCDC120 CCDC13 CCDC146 CCDC150 CCDC17 CCDC185 CCDC187 CCDC198 CCDC70 CCDC87 CCDC92 CCHCR1 CCNC CCNH CDC20B CDC37 CDC5L CDC7 CDC73 CDCA7L CDK1 CDK18 CDKL3 CDKN1A CENPP CEP55 CEP57L1 CEP95 CHCHD2 CHCHD3 CIC CINP CKB CLIP3 COG6 CORO1A COX5B CRACR2A CRMP1 CSPP1 CSTF2T CUL5 CWF19L2 CYB5R2 DAXX DCTN4 DCX DDX6 DEUP1 DGCR6 DLGAP3 DLGAP5 DLX6-AS1 DMTN DNM2 DTX2 DVL2 EAF2 EFCAB6 EFHC1 EGR2 EIF3G EIF4A2 ENKD1 ENPP7 EP300 ERCC3 ESCO2 EXOC8 EXOSC5 FAM110A FAM124B FAM126B FAM161A FAM161B FAM184A FAM193B FAM207A FAM214A FAM214B FAM50B FAM90A1 FANCG FBF1 FBXL18 FBXO28 FIP1L1 FNDC11 FOXC2 GADD45GIP1 GAS2L2 GAS8 GATA1 GATA2 GATAD2B GCC1 GEM GFAP GGA2 GGN GLYCTK GMCL1 GNG5 GNL3L GORASP1 GORASP2 GPANK1 GPKOW GPS2 GRAP2 GRB14 GSE1 GTPBP10 GZMA GZMK HAUS1 HDAC4 HGS HOXB5 HOXB9 HTRA1 HYLS1 IFT20 IFT27 IGFN1 IHO1 IKZF3 IL16 INPP5J IQCE IQUB ISCU ITGB5 ITPKB ITSN2 KANK2 KANSL1 KAT5 KDM1A KIAA1217 KIFC3 KRT1 KRT18 KRT6A KRT6B KRT6C KRT75 L3MBTL2 LASP1 LATS1 LCOR LCP2 LENG1 LGALS3 LHX4 LIMS2 LIN7A LINGO1 LMNB2 LMO1 LMO2 LMO3 LMO4 LYPLA1 LYSMD1 MAB21L2 MAGOH MAGOHB MBD3 MCM10 MCM7 MCRS1 MFAP1 MID2 MISP MNAT1 MORF4L1 MORF4L2 MORN3 MOS MSRB3 MTFR2 MVP MYEF2 NCF2 NDC80 NDE1 NDEL1 NDN NDUFA5 NEBL NECAB2 NEFL NME7 NOS3 NOTCH1 NSMF NTAQ1 NUDT21 NXT2 OAS1 ODAD4 ORC1 PACRGL PARD6B PATL1 PCM1 PIAS2 PIBF1 PID1 PIK3R2 PIMREG PIN1 PITX1 PKN1 PKN3 PKP1 PKP2 PKP4 PLAAT5 PLEKHA2 POLDIP3 POLR3C POM121 POU4F3 PPP1R16B PPP1R18 PPP1R32 PPP2CA PQBP1 PRAM1 PRKAA1 PRKAA2 PRKAB2 PRPF18 PRPF3 PRPF31 PSMA1 PSMA4 PTBP2 PTPN11 PTPN21 RAB1A RAB1B RAB2A RAB2B RAB33B RAB39A RAB39B RAB6A RAD18 RAMAC RANBP3 RANBP3L RBL1 RBM17 RBM22 RBM25 RBM39 RBM41 RCL1 RCOR3 RGS8 RHNO1 RHOJ RHPN1 RIBC1 RIN1 RITA1 RNF135 RNF169 RNF213 RNF214 RNF6 RSPH14 RSRC2 RTP5 RUSC2 RXRB SAMD4A SAP30BP SCAF8 SCEL SCNM1 SECISBP2 SELENOV SFI1 SH2D4A SH3GLB2 SH3RF2 SHC3 SHISA6 SLU7 SMARCB1 SMARCE1 SMCP SMG9 SNAP47 SNF8 SNRPB SNRPB2 SNRPC SNTA1 SNW1 SNX18 SORBS2 SPATA18 SPATA2 SPATA22 SPG21 SRSF2 SSX2IP STAC STAMBPL1 STK25 STK26 STN1 SUDS3 SUGP2 SUPT5H SYNPO2L SYT17 SYT6 TBC1D22B TBC1D30 TBP TCEA2 TCEANC TCF19 TCL1A TDP2 TEAD4 TEPSIN TEX9 TFAP4 TFIP11 THAP7 THYN1 TLE5 TMED2 TPM1 TPRX1 TPX2 TRAF1 TRAF3IP2 TRAF4 TRAF5 TRIM14 TRIM29 TRIM42 TSC22D4 TSGA10 TSGA10IP TSHZ2 TSHZ3 TSSC4 TSSK3 TTC23 TTC9C TTPA TUBGCP4 TXLNA TXLNB UBE2H UBE2I UBE2U UBE3C UBTFL1 USO1 USP15 USP2 UTP14C UTP23 VPS28 VPS37C WASHC3 WHRN WT1 XIAP YJU2 YTHDC1 ZBTB16 ZBTB4 ZBTB42 ZC2HC1C ZFC3H1 ZFHX3 ZFP2 ZFYVE26 ZG16B ZGPAT ZMAT1 ZMAT2 ZNF124 ZNF250 ZNF280C ZNF3 ZNF35 ZNF410 ZNF414 ZNF417 ZNF438 ZNF48 ZNF488 ZNF512B ZNF524 ZNF572 ZNF581 ZNF587 ZNF594 ZNF648 ZNF688 ZNF774 ZNF835 ZZZ3
Entrez ID		9759	2801
HPRD ID		05610	03989
Ensembl ID		ENSG00000068024	ENSG00000167110
Uniprot IDs		P56524	Q08379
PDB IDs		2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31 4CBT 4CBY 5A2S 5ZOO 5ZOP 6FYZ	4REY 6IW8 6IWA 6K06
Enriched GO Terms of Interacting Partners?
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