KMT2B and NREP

Data Source:
BioGRID (two hybrid)

		KMT2B	NREP
Description		lysine methyltransferase 2B	neuronal regeneration related protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nucleus Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding	Protein Binding
	Biological Process	Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation Histone H3-K4 Monomethylation	Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Regulation Of Neuron Differentiation
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Refractive error ( 32231278)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683) Gut microbiota relative abundance (Sutterella) ( 33208821) Hematocrit ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Reaction time ( 29844566) Red blood cell count ( 29403010 32888494) Thyroid cancer ( 28195142)
Interacting Genes		27 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TRIM55 TRIM63 TSC22D1 ZNF512B	5 interacting genes: ATM EEF1A1 EIF3B IGSF21 KMT2B
Entrez ID		9757	9315
HPRD ID		06017	09545
Ensembl ID		ENSG00000272333	ENSG00000134986
Uniprot IDs		Q9UMN6	Q16612
PDB IDs		3UVM 4ERZ 4PZI 7BRE
Enriched GO Terms of Interacting Partners?
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