UBE3C and CAND2

Data Source:
HPRD (in vitro, in vivo)

		UBE3C	CAND2
Description		ubiquitin protein ligase E3C	cullin associated and neddylation dissociated 2 (putative)
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus	Nucleus Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding TBP-class Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process	SCF Complex Assembly Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 25673413) Language impairment in frontotemporal lobe dementia ( 29724592) Quantitative traits ( 19197348) Response to citalopram treatment ( 19846067) Type 2 diabetes ( 30054458)	Atrial fibrillation ( 30061737 29892015) Creatine kinase levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HOMA-B (corrected for HOMA-IR) ( 30369944) P wave duration ( 28794112) Waist circumference adjusted for body mass index ( 28552196) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: APP CAND2 CCNB1 GOLGA2 MTA2 PSMC5 PSMD2 TLK1 UBE2D1 UBE2D2 UBE2D3 UBE2L3	9 interacting genes: CIDEB CNOT3 DNAJB6 FHL2 GLP1R RBX1 SYP TBP UBE3C
Entrez ID		9690	23066
HPRD ID		15604	19120
Ensembl ID		ENSG00000009335	ENSG00000144712
Uniprot IDs		Q15386	O75155
PDB IDs		6K2C
Enriched GO Terms of Interacting Partners?
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