IQCB1 and CD80

Data Source:
BioGRID (affinity chromatography technology)

		IQCB1	CD80
Description		IQ motif containing B1	CD80 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleoplasm Centrosome Centriole Cytosol Cilium Microtubule Cytoskeleton Photoreceptor Connecting Cilium Intercellular Bridge Extracellular Exosome Mitotic Spindle	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Protein Complex Involved In Cell Adhesion
	Molecular Function	Protein Binding Calmodulin Binding Enzyme Binding	Virus Receptor Activity Protein Binding Coreceptor Activity
	Biological Process	Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Cilium Assembly Ciliary Basal Body-plasma Membrane Docking	Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-2 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide
Pathways		Anchoring of the basal body to the plasma membrane	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Abatacept Galiximab Belatacept
Diseases		Senior-Loken syndrome
GWAS		Hemoglobin levels ( 32327693) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376)	Asthma ( 32296059) Autoimmune thyroid disease ( 32581359) Carotid plaque burden ( 28282560) Celiac disease ( 20190752) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lobular breast cancer (menopausal hormone therapy interaction) ( 24080446) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269 28062665) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 23273568 25862617) Systemic sclerosis ( 31672989) Vitiligo ( 27723757 22561518)
Interacting Genes		12 interacting genes: CALM2 CALML3 KIF9 LDOC1 MARCHF7 MNS1 PCMT1 PDE9A SESTD1 SMARCD1 SPG21 TRIM32	5 interacting genes: CD274 CD28 CD86 CTLA4 NGFR
Entrez ID		9657	941
HPRD ID		11049	00202
Ensembl ID		ENSG00000173226	ENSG00000121594
Uniprot IDs		Q15051	A0N0P2 P33681
PDB IDs			1DR9 1I8L
Enriched GO Terms of Interacting Partners?
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