CD80 and CTLA4

Data Source:
HPRD (in vitro)

		CD80	CTLA4
Description		CD80 molecule	cytotoxic T-lymphocyte associated protein 4
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Protein Complex Involved In Cell Adhesion	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity	Protein Binding
	Biological Process	Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-2 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Lipopolysaccharide	Adaptive Immune Response Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs		Abatacept Galiximab Belatacept	Ipilimumab Tremelimumab
Diseases			Type I diabetes mellitus Graves' disease Allograft rejection Hashimoto's thyroiditis
GWAS		Asthma ( 32296059) Autoimmune thyroid disease ( 32581359) Carotid plaque burden ( 28282560) Celiac disease ( 20190752) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lobular breast cancer (menopausal hormone therapy interaction) ( 24080446) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269 28062665) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 23273568 25862617) Systemic sclerosis ( 31672989) Vitiligo ( 27723757 22561518)	Alopecia areata ( 20596022 25608926) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 27182965 22493691) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 30423114 30572963 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 30659077 21829393 25751624 19430480 30572963 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)
Interacting Genes		5 interacting genes: CD274 CD28 CD86 CTLA4 NGFR	17 interacting genes: AP1M1 AP2M1 CD80 CD86 CTXN3 FYN JAK2 LCK LYN MALL PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TMEM218 TXK
Entrez ID		941	1493
HPRD ID		00202	00474
Ensembl ID		ENSG00000121594	ENSG00000163599
Uniprot IDs		A0N0P2 P33681	P16410
PDB IDs		1DR9 1I8L	1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3 6RP8 6RPJ 6RQM
Enriched GO Terms of Interacting Partners?
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