GCC2 and ICAM3

Data Source:
BioGRID (biochemical)

		GCC2	ICAM3
Description		GRIP and coiled-coil domain containing 2	intercellular adhesion molecule 3
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GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding Identical Protein Binding	Signaling Receptor Binding Integrin Binding Protein Binding
	Biological Process	Protein Targeting To Lysosome Microtubule Organizing Center Organization Protein Localization To Golgi Apparatus Microtubule Anchoring Late Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Regulation Of Protein Exit From Endoplasmic Reticulum Recycling Endosome To Golgi Transport Golgi Ribbon Formation	Stimulatory C-type Lectin Receptor Signaling Pathway Phagocytosis Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion
Pathways		Retrograde transport at the Trans-Golgi-Network	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling
Drugs
Diseases
GWAS		Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 27863252) Platelet distribution width ( 32888494)	Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		3 interacting genes: ARL1 SPOP SRPK2	20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16
Entrez ID		9648	3385
HPRD ID		11001	00889
Ensembl ID		ENSG00000135968	ENSG00000076662
Uniprot IDs		B3KR21 Q8IWJ2	A0A024R7C1 K7ERN2 P32942
PDB IDs		3BBP	1T0P
Enriched GO Terms of Interacting Partners?
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