ICAM3 and ITGAL

Data Source:
HPRD (in vitro, in vivo)

		ICAM3	ITGAL
Description		intercellular adhesion molecule 3	integrin subunit alpha L
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome	Plasma Membrane Integrin Complex Cell Surface Membrane Integrin AlphaL-beta2 Complex Specific Granule Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Integrin Binding Protein Binding	Protein Binding ICAM-3 Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Phagocytosis Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phagocytosis Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Viral Process Extracellular Matrix Organization Memory T Cell Extravasation Receptor Clustering Neutrophil Degranulation Regulation Of Immune Response Leukocyte Migration Cell-cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Neutrophil degranulation RUNX3 Regulates Immune Response and Cell Migration
Drugs			Efalizumab Antithymocyte immunoglobulin (rabbit) Lovastatin Simvastatin Rosuvastatin 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine LFA703 (S)-2-((S)-3-isobutyl-2,5-dioxo-4-quinolin-3-ylmethyl-[1,4]diazepan-1yl)-N-methyl-3-naphtalen-2-yl-propionamide 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline Pitavastatin Lifitegrast
Diseases
GWAS		Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Smooth-surface caries ( 24556642) Ulcerative colitis ( 28067908 23128233) White blood cell count ( 32888494 27863252)
Interacting Genes		20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16	7 interacting genes: F11R ICAM1 ICAM3 ICAM5 PTPRC RANBP9 SHARPIN
Entrez ID		3385	3683
HPRD ID		00889	01079
Ensembl ID		ENSG00000076662	ENSG00000005844
Uniprot IDs		A0A024R7C1 K7ERN2 P32942	B2RAL6 P20701
PDB IDs		1T0P	1CQP 1DGQ 1IJ4 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2M3E 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX 4IXD 5E6R 5E6S 5E6U 6BXB 6BXF 6BXJ 6CKB
Enriched GO Terms of Interacting Partners?
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