RGS6 and AREL1

Data Source:
BioGRID (affinity chromatography technology)

		RGS6	AREL1
Description		regulator of G protein signaling 6	apoptosis resistant E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Extrinsic Component Of Membrane	Cytoplasm Cytosol
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response
Pathways		G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral density (hip) ( 30172743) C-reactive protein levels ( 30388399 21300955) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous psoriasis ( 26626624) Economic and political preferences (environmentalism) ( 22566634) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Heart rate ( 28610988) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Intracranial aneurysm ( 29531279) Neuroticism ( 29255261) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 21935397) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Resting heart rate ( 29769521 27798624) Schizophrenia ( 28991256 25056061 29483656 30285260) Small cell lung carcinoma ( 28604730) Smoking cessation ( 20811658) Systolic blood pressure ( 30224653 30578418) Transverse temporal cortex volume ( 31530798) Yang-deficiency constitution ( 25533513)	General factor of neuroticism ( 30867560) Mood instability ( 29187730)
Interacting Genes		4 interacting genes: DMAP1 DNMT1 GNB5 STMN2	10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		9628	9870
HPRD ID		04871	13794
Ensembl ID		ENSG00000182732	ENSG00000119682
Uniprot IDs		B7Z2A0 B7Z2N1 P49758 Q2M3K2	O15033
PDB IDs		2ES0	6JX5
Enriched GO Terms of Interacting Partners?
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