CD44 and KDELR2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CD44	KDELR2
Description		CD44 molecule (Indian blood group)	KDEL endoplasmic reticulum protein retention receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Microvillus Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cis-Golgi Network Integral Component Of Membrane Transport Vesicle COPI-coated Vesicle Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	KDEL Sequence Binding ER Retention Sequence Binding
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hyaluronan Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cartilage Development Interferon-gamma-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	Protein Retention In ER Lumen Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Integrin cell surface interactions Hyaluronan uptake and degradation Neutrophil degranulation Interferon gamma signaling	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Bivatuzumab Hyaluronic acid
Diseases		Gastric cancer
GWAS		Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 27723757 22561518)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Blood protein levels ( 29875488) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 25248455) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Red cell distribution width ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		61 interacting genes: ABCB5 AKT1 ANK1 ARHGEF1 ARHGEF12 ARNT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK DMP1 EGFR EPB41 EPHA2 ERBB2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK MADCAM1 MAP2K3 MAP2K5 MDM4 MET MMP1 MMP7 MMP9 MSN NF2 PDGFRA PKN1 RAF1 SELE SPP1 SRC SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	22 interacting genes: AKT1 BECN1 CCND2 CD44 CDK4 CDK6 CDKN2B EPHA2 ERBB2 FGFR4 GRM1 IGF1R KAT2A LATS2 MAP2K3 MET MYC NF2 PDGFRA RASSF1 STK11 TTYH2
Entrez ID		960	11014
HPRD ID		00115	06598
Ensembl ID		ENSG00000026508	ENSG00000136240
Uniprot IDs		P16070	A0A024QZT7 P33947
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS
Enriched GO Terms of Interacting Partners?
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