CD40 and FAF1

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid)

		CD40	FAF1
Description		CD40 molecule	Fas associated factor 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface CD40 Receptor Complex Neuronal Cell Body Varicosity Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Nuclear Envelope Nucleoplasm Cytosol CD95 Death-inducing Signaling Complex VCP-NPL4-UFD1 AAA ATPase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Antigen Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Inflammatory Response CD40 Signaling Pathway Platelet Activation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-12 Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Cobalamin Response To Interferon-gamma TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Erythropoietin B Cell Proliferation B Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Protozoan Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Kinase C Signaling Response To Peptide Positive Regulation Of Endothelial Cell Apoptotic Process	Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Catabolic Process
Pathways
Drugs		Lucatumumab Dacetuzumab
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 22446961 33106546 22446962) Multiple sclerosis ( 22190364 24076602 19525955 21833088) Rheumatoid arthritis ( 30423114 18794853 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469) Tonsillectomy ( 27182965 28928442)	Atrial fibrillation ( 29290336) Blood urea nitrogen levels ( 31152163) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Depression and alcohol dependence ( 22064162) FEV1 ( 30804560) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean reticulocyte volume ( 32888494) Multisite chronic pain ( 31194737) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Postprandial triglyceride response ( 32603185) Pulse pressure ( 27841878 30578418) QRS duration ( 30679814 21076409) Renal cell carcinoma ( 28598434) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Type 2 diabetes ( 24509480 30297969 26818947 32499647 30718926 28869590) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)
Interacting Genes		44 interacting genes: BIRC2 BIRC3 CAV1 CBL CD40LG CMTM5 CMTM6 CYB561A3 DEFB121 EBP FAF1 HSPA4 HSPA8 IL4R INSIG2 JAK3 MAL MAP3K8 MFSD5 MIP MS4A1 NCOA6 NSMAF PIK3R1 PLP1 RIPK2 SLC30A2 SLC30A3 SLC39A13 SLC7A1 TANK TDP2 TLCD1 TMEM107 TMEM128 TMEM147 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 XRCC5 XRCC6	46 interacting genes: AKT1 ANXA1 ANXA7 ASCC2 CASP8 CD40 CDC73 CDKN1A CREBBP CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 HSPA1B IGF2 IKBKB ITGB1BP1 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 PRKN RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 SPOP SUMO1 TAF1D TK1 TNNT1 TSC22D1 UBC UBE2I UROD XIAP YTHDF3
Entrez ID		958	11124
HPRD ID		00178	05124
Ensembl ID		ENSG00000101017	ENSG00000185104
Uniprot IDs		A0A0S2Z349 A0A0S2Z3C7 P25942 Q6P2H9	Q9UNN5
PDB IDs		1CDF 1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL 6FAX 6PE8 6PE9	1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M
Enriched GO Terms of Interacting Partners?
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