CLOCK and PPP1CC

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CLOCK	PPP1CC
Description		clock circadian regulator	protein phosphatase 1 catalytic subunit gamma
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytosol Chromatoid Body Intracellular Membrane-bounded Organelle CLOCK-BMAL Transcription Complex	Protein Phosphatase Type 1 Complex Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein-containing Complex Dendritic Spine PTW/PP1 Phosphatase Complex Presynapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Lamin Binding Protein C-terminus Binding Protein Phosphatase 1 Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	DNA Damage Checkpoint Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Acetylation Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Histone Acetylation Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway	Glycogen Metabolic Process Protein Dephosphorylation Cell Cycle Neuron Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleocytoplasmic Transport Cell Division Positive Regulation Of Glial Cell Proliferation
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression HATs acetylate histones Circadian Clock	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Circadian Clock RHO GTPases Activate Formins RAF activation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Signaling by MRAS-complex mutants
Drugs			9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 33020668) Cortical surface area (MOSTest) ( 32665545) Height ( 25282103) Neutrophil percentage of white cells ( 32888494) Personality dimensions ( 18957941) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Heart rate ( 23583979)
Interacting Genes		26 interacting genes: ARNTL ARNTL2 BHLHE41 CRY1 CRY2 CSNK1E CSNK2B DBP DELEC1 EP300 KAT2B NPAS2 PER2 PER3 PPP1CA PPP1CB PPP1CC PPP2R1B PPP2R5D PPP2R5E RARA RHOA RORB RORC RXRA SIRT1	131 interacting genes: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C14orf180 C1QA C9orf50 CEP126 CLMN CLOCK CLTC CNST COPS5 CSNK1A1 CSNK1E CSNK2B CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DELEC1 DYNLT4 DYRK4 EIF2AK2 ELP4 ENKD1 FBXW11 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IFTAP IL3RA INSYN1 JAK2 KCTD20 KDM4D KRCC1 LMTK2 MAP4K4 MAPT MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 POLR1F PPP1R11 PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R2B PPP1R2C PPP1R32 PPP1R35 PPP1R3A PPP1R3B PPP1R3C PPP1R3D PPP1R7 PPP1R8 PPP1R9A PPP1R9B PPP2R5C PRR16 RAF1 RB1 RIF1 RNF19B RORC RPL7 RPRD2 RRM1 RRP1B SDR39U1 SFRP1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 SUMO2 TACC2 TBC1D19 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF629 ZNF667
Entrez ID		9575	5501
HPRD ID		03508	08911
Ensembl ID		ENSG00000134852	ENSG00000186298
Uniprot IDs		O15516 Q3ZCT4 Q53EU0	A0A024RBP2 P36873
PDB IDs		4H10 6QPJ	1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3 5INB 5J28
Enriched GO Terms of Interacting Partners?
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