MYOT and LRP12

Data Source:
HPRD (in vivo, two hybrid)

		MYOT	LRP12
Description		myotilin	LDL receptor related protein 12
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Actin Cytoskeleton Z Disc Axon Sarcolemma Neuronal Cell Body	Integral Component Of Plasma Membrane Clathrin-coated Pit Integral Component Of Membrane
	Molecular Function	Actin Binding Protein Binding Axon Guidance Receptor Activity Structural Constituent Of Muscle Alpha-actinin Binding	Low-density Lipoprotein Particle Receptor Activity Protein Binding
	Biological Process	Muscle Contraction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Synapse Organization	Neuron Migration Endocytosis Signal Transduction Neuron Projection Development Regulation Of Growth
Pathways			Retinoid metabolism and transport
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Limb-girdle muscular dystrophy (LGMD)
GWAS		Atrial fibrillation ( 30061737) Heart rate ( 23583979) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)	Blood protein levels ( 30072576) Glaucoma (primary open-angle) ( 22570617) HOMA-B (corrected for HOMA-IR) ( 30369944) Impulsivity (attentional) ( 30718321) Irritable mood ( 29500382) Periodontitis (DPAL) ( 24024966) Systolic blood pressure ( 28739976) Vascular endothelial growth factor levels ( 21757650)
Interacting Genes		17 interacting genes: ACTN1 ACTN2 ACTN3 APP AXIN1 DOCK9 FLNA FLNC GPRASP2 LRP12 NME7 PDLIM3 PFDN5 ST7 TFG TRIM55 TRIM63	6 interacting genes: ACTN2 MYOT NMRK2 RACK1 SNAPIN ZFYVE9
Entrez ID		9499	29967
HPRD ID		04981	17447
Ensembl ID		ENSG00000120729	ENSG00000147650
Uniprot IDs		A0A0C4DFM5 B4DT68 Q9UBF9	Q59H02 Q9Y561
PDB IDs		2KDG 2KKQ
Enriched GO Terms of Interacting Partners?
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