FHL5 and TUSC2

Data Source:
BioGRID (two hybrid)

		FHL5	TUSC2
Description		four and a half LIM domains 5	tumor suppressor 2, mitochondrial calcium regulator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Z Disc	Mitochondrion
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Natural Killer Cell Differentiation Phagocytosis Inflammatory Response Cell Cycle Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-10 Production Cell Maturation Regulation Of Mitochondrial Membrane Potential Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS		Cerebral blood flow ( 28627999) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		90 interacting genes: ABI2 ADAM12 ADAMTSL5 AGXT ANKRD55 ANKS1A BANP BBC3 BCL6B CATSPER1 CDC20B CFP CNNM3 COIL CREB1 CREM CRYBA2 CRYBA4 CTSZ DCDC2B DLGAP4 DMRT3 DNAL4 DTX2 FAM214B FAM71C FARS2 FEZF1 FHL2 GPS2 GSTP1 HAPLN2 HCK HDX HEY2 HOXA1 HOXB9 IL16 IP6K3 KIF17 KIR2DL4 LMO2 LRRC41 MAGOHB MISP MYOZ3 NEK6 NPDC1 NUFIP2 OTX1 PIN1 PLEKHA2 PLEKHN1 PPP1R18 PPP1R32 QRICH1 RAB26 RAB3IL1 RPS21 SAXO1 SCNM1 SDCBP SEC31A SHFL SLIT1 SMAD1 SPRY1 SRF TUSC2 TXN2 YPEL3 ZBTB16 ZNF124 ZNF131 ZNF23 ZNF250 ZNF251 ZNF408 ZNF417 ZNF440 ZNF446 ZNF564 ZNF581 ZNF587 ZNF613 ZNF688 ZNF764 ZNF766 ZNF792 ZNHIT1	4 interacting genes: FHL5 MAPK9 MDFI RBPMS
Entrez ID		9457	11334
HPRD ID		05497	06134
Ensembl ID		ENSG00000112214	ENSG00000114383
Uniprot IDs		Q5TD97	O75896
PDB IDs		1X68
Enriched GO Terms of Interacting Partners?
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