CD14 and IRAK3

Data Source:
BioGRID (two hybrid)

		CD14	IRAK3
Description		CD14 molecule	interleukin 1 receptor associated kinase 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Lipopolysaccharide Binding Opsonin Receptor Activity Protein Binding Peptidoglycan Immune Receptor Activity Lipoteichoic Acid Binding Lipopeptide Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Receptor-mediated Endocytosis Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Heat Lipopolysaccharide-mediated Signaling Pathway Response To Magnesium Ion Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Neutrophil Degranulation Innate Immune Response Response To Ethanol Positive Regulation Of Endocytosis Response To Electrical Stimulus Necroptotic Process Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide Apoptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Negative Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling
Drugs			Fostamatinib
Diseases		Asthma
GWAS		Blood protein levels ( 30072576) Refractive error ( 32231278) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)	Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)
Interacting Genes		14 interacting genes: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 TLR2 TLR3 TLR4 TNFRSF1B	17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6
Entrez ID		929	11213
HPRD ID		01151	05123
Ensembl ID		ENSG00000170458	ENSG00000090376
Uniprot IDs		P08571	Q9Y616
PDB IDs		4GLP	5UKE 6RUU 6ZIW
Enriched GO Terms of Interacting Partners?
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