UBE2L6 and RNF150

Data Source:
BioGRID (two hybrid)

		UBE2L6	RNF150
Description		ubiquitin conjugating enzyme E2 L6	ring finger protein 150
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol	Cytoplasm Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding ISG15 Transferase Activity Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity	Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Phosphopantetheinylation Translesion Synthesis ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Cellular Protein Metabolic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Malaria ( 31844061) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Refractive error ( 32231278)
Interacting Genes		40 interacting genes: ARHGDIA ARIH1 ARIH2 CBLC DTX3 FLT3 HERC5 LONRF1 MAP3K1 MID1 MUL1 NEDD4L PJA2 PRKN RBCK1 RBX1 RNF122 RNF125 RNF144A RNF144B RNF150 RNF19A RNF216 RNF25 RNF4 RNF40 RUNX1 SIAH1 SIAH2 SPEN TOPORS TRAF7 TRIM25 TRIM27 TRIM62 TRIM8 UBA1 UBA6 UBA7 UBE3A	12 interacting genes: C3orf52 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2L3 UBE2L6 UBE2U UBE2W UBE2Z
Entrez ID		9246	57484
HPRD ID		04867	15258
Ensembl ID		ENSG00000156587	ENSG00000170153
Uniprot IDs		O14933	D6RIE5 Q9ULK6
PDB IDs		1WZV 1WZW 2KJH
Enriched GO Terms of Interacting Partners?
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