CD5L and CD40LG

Data Source:
HPRD (in vivo)

		CD5L	CD40LG
Description		CD5 molecule like	CD40 ligand
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Cell Surface Blood Microparticle	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity	Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Integrin Binding Protein Binding
	Biological Process	Immune System Process Endocytosis Apoptotic Process Inflammatory Response Cellular Defense Response Regulation Of Complement Activation Zymogen Activation Positive Regulation Of Complement-dependent Cytotoxicity	Regulation Of Immunoglobulin Production Inflammatory Response Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity CD40 Signaling Pathway Platelet Activation B Cell Differentiation T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-4 Production Tumor Necrosis Factor-mediated Signaling Pathway B Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Isotype Switching Regulation Of Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs			Ruplizumab
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS			CD40 ligand levels ( 25147954) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494)
Interacting Genes		1 interacting genes: CD40LG	6 interacting genes: CD40 CD5L IGHG1 IGKC RNF128 TP53
Entrez ID		922	959
HPRD ID		03997	02311
Ensembl ID		ENSG00000073754	ENSG00000102245
Uniprot IDs		O43866	P29965
PDB IDs			1ALY 1I9R 3LKJ 3QD6 6BRB
Enriched GO Terms of Interacting Partners?
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