ZMYM5 and CBS

Data Source:
BioGRID (two hybrid)

		ZMYM5	CBS
Description		zinc finger MYM-type containing 5	cystathionine beta-synthase
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GO Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding	Cystathionine Beta-synthase Activity Protein Binding Oxygen Binding Enzyme Binding Heme Binding Pyridoxal Phosphate Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Nitrite Reductase (NO-forming) Activity Carbon Monoxide Binding Nitric Oxide Binding Modified Amino Acid Binding S-adenosyl-L-methionine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II	Cysteine Biosynthetic Process From Serine L-serine Metabolic Process L-serine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration L-cysteine Catabolic Process DNA Protection Homocysteine Catabolic Process Homocysteine Metabolic Process Hydrogen Sulfide Biosynthetic Process
Pathways			Cysteine formation from homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs			Pyridoxal phosphate Ademetionine Serine Cysteine
Diseases			Homocystinuria
GWAS		Alcohol use disorder (consumption score) ( 30940813) Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Methadone dose in opioid dependence ( 28115739)	Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Homocysteine levels ( 23824729 20031578) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Plasma homocysteine levels (post-methionine load test) ( 24651765) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		29 interacting genes: APP CAMK2B CARD9 CBS CBSL CREBBP DAPK1 DES FADD FBXO7 GTF2IRD1 HMBOX1 HOMER1 LCE3B LRRK2 MFHAS1 PAX5 PRMT1 SKIL SNIP1 SUMO1 SUMO2 TFG TRAF2 TRAF4 TRIP13 UBQLN1 ZBTB26 ZNRD2	23 interacting genes: CBX4 CERT1 DAXX EHHADH FXR2 HGS HID1 HTT NTAQ1 PIAS1 PIAS2 PIAS3 PIN1 PRKAG1 PRKAR1A PSMA1 RANBP9 UBASH3A UBE2I UGP2 VTA1 ZDHHC17 ZMYM5
Entrez ID		9205	875
HPRD ID		10324	01994
Ensembl ID		ENSG00000132950	ENSG00000160200
Uniprot IDs		Q9UJ78	B7Z2D6 P0DN79 P35520 Q9NTF0
PDB IDs		2DAS	1JBQ 1M54 4COO 4L0D 4L27 4L28 4L3V 4PCU 4UUU 5MMS
Enriched GO Terms of Interacting Partners?
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